Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4470223..4471055 Replicon chromosome
Accession NZ_CP027312
Organism Escherichia coli strain 2013C-3181

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MJ73_RS23135 Protein ID WP_000854816.1
Coordinates 4470223..4470597 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MJ73_RS23140 Protein ID WP_001285402.1
Coordinates 4470687..4471055 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ73_RS23095 4465242..4465778 + 537 WP_000942795.1 GspM family type II secretion system protein YghD -
MJ73_RS23100 4466059..4466373 - 315 Protein_4194 DUF4942 domain-containing protein -
MJ73_RS23105 4466392..4468005 - 1614 WP_106918514.1 IS66 family transposase -
MJ73_RS23110 4468036..4468386 - 351 WP_000624684.1 IS66 family insertion sequence element accessory protein TnpB -
MJ73_RS23115 4468383..4468808 - 426 WP_000422722.1 IS66 family insertion sequence hypothetical protein -
MJ73_RS23120 4468893..4469441 - 549 Protein_4198 DUF4942 domain-containing protein -
MJ73_RS23125 4469526..4469723 - 198 WP_032209866.1 DUF957 domain-containing protein -
MJ73_RS23130 4469735..4470226 - 492 WP_000976864.1 hypothetical protein -
MJ73_RS23135 4470223..4470597 - 375 WP_000854816.1 type IV toxin-antitoxin system toxin CbtA Toxin
MJ73_RS23140 4470687..4471055 - 369 WP_001285402.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ73_RS23145 4471218..4471439 - 222 WP_000692323.1 DUF987 domain-containing protein -
MJ73_RS23150 4471508..4471984 - 477 WP_001186727.1 RadC family protein -
MJ73_RS23155 4472000..4472479 - 480 WP_000706981.1 antirestriction protein -
MJ73_RS23160 4472742..4473560 - 819 WP_001234638.1 DUF945 domain-containing protein -
MJ73_RS23170 4473651..4473884 - 234 Protein_4207 DUF905 domain-containing protein -
MJ73_RS23175 4473959..4474414 - 456 WP_024226900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14045.05 Da        Isoelectric Point: 9.1493

>T97882 WP_000854816.1 NZ_CP027312:c4470597-4470223 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

>T97882 NZ_CP027312:c4470597-4470223 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCGCGTCCGTCTCCTGTTGAAATCTGGCAGACACTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13883.62 Da        Isoelectric Point: 6.3165

>AT97882 WP_001285402.1 NZ_CP027312:c4471055-4470687 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELILTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT97882 NZ_CP027312:c4471055-4470687 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATACTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References