Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3676832..3677630 Replicon chromosome
Accession NZ_CP027312
Organism Escherichia coli strain 2013C-3181

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7MZH4
Locus tag MJ73_RS18995 Protein ID WP_001094453.1
Coordinates 3676832..3677209 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7WAC0
Locus tag MJ73_RS19000 Protein ID WP_001285601.1
Coordinates 3677256..3677630 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ73_RS18960 3672197..3673120 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
MJ73_RS18965 3673231..3674415 - 1185 WP_001172876.1 sugar efflux transporter -
MJ73_RS18980 3675208..3676053 - 846 WP_001280520.1 DUF4942 domain-containing protein -
MJ73_RS18985 3676138..3676335 - 198 WP_000839249.1 DUF957 domain-containing protein -
MJ73_RS18990 3676347..3676835 - 489 WP_000761711.1 hypothetical protein -
MJ73_RS18995 3676832..3677209 - 378 WP_001094453.1 TA system toxin CbtA family protein Toxin
MJ73_RS19000 3677256..3677630 - 375 WP_001285601.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ73_RS19005 3677793..3678014 - 222 WP_000692296.1 DUF987 domain-containing protein -
MJ73_RS19010 3678083..3678559 - 477 WP_158707527.1 RadC family protein -
MJ73_RS19015 3678526..3679059 - 534 WP_000849595.1 antirestriction protein -
MJ73_RS19020 3679114..3679932 - 819 WP_044808380.1 DUF945 domain-containing protein -
MJ73_RS19025 3680022..3680255 - 234 WP_001117559.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14181.04 Da        Isoelectric Point: 5.5831

>T97879 WP_001094453.1 NZ_CP027312:c3677209-3676832 [Escherichia coli]
MNTLPDTHVRETSGCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T97879 NZ_CP027312:c3677209-3676832 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13653.47 Da        Isoelectric Point: 5.5769

>AT97879 WP_001285601.1 NZ_CP027312:c3677630-3677256 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT97879 NZ_CP027312:c3677630-3677256 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCGGATTCGTACCACCTGGAGCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References