Detailed information of TA system TA097837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 943772..944816
• Replicon: chromosome
• Accession: NZ_CP027310
• Organism: Escherichia coli strain 2014C-4135

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: C6N22_RS04895
• Protein ID: WP_032209643.1
• Coordinates: 943772..944320 (-)
• Length: 183 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A839B6W4
• Locus tag: C6N22_RS04900
• Protein ID: WP_000287252.1
• Coordinates: 944343..944816 (-)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N22_RS04850	939361..939723	+	363	WP_000135680.1	hypothetical protein	-
C6N22_RS04855	939789..940613	+	825	WP_000081287.1	DUF2303 family protein	-
C6N22_RS04860	940742..941278	+	537	WP_032209649.1	5'-deoxynucleotidase	-
C6N22_RS04865	941269..942147	+	879	WP_032209648.1	phosphoadenosine phosphosulfate reductase family protein	-
C6N22_RS04870	942144..942347	+	204	WP_000156999.1	hypothetical protein	-
C6N22_RS04875	942340..942579	+	240	WP_000476212.1	hypothetical protein	-
C6N22_RS04880	942576..942887	+	312	WP_032209646.1	hypothetical protein	-
C6N22_RS04885	942887..943429	+	543	WP_032209645.1	3'-5' exoribonuclease	-
C6N22_RS04890	943466..943738	+	273	WP_032209644.1	pyocin activator PrtN family protein	-
C6N22_RS04895	943772..944320	-	549	WP_032209643.1	hypothetical protein	Toxin
C6N22_RS04900	944343..944816	-	474	WP_000287252.1	SocA family protein	Antitoxin
C6N22_RS04905	945103..945225	-	123	WP_001300034.1	hypothetical protein	-
C6N22_RS04910	945589..946578	-	990	Protein_888	DUF2713 domain-containing protein	-
C6N22_RS04920	946896..947411	+	516	WP_001295691.1	zinc uptake transcriptional repressor Zur	-
C6N22_RS04925	947453..947662	-	210	WP_001030593.1	CsbD family protein	-
C6N22_RS04930	947778..949103	-	1326	WP_001298861.1	MATE family efflux transporter DinF	-
C6N22_RS04935	949176..949784	-	609	WP_000646078.1	transcriptional repressor LexA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	stx2B / stx2A	890418..944816	54398

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-123)

Sequences

Toxin

Protein

• Length: 183 a.a.
• Molecular weight: 19937.30 Da
• Isoelectric Point: 4.3763

>T97837 WP_032209643.1 NZ_CP027310:c944320-943772 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFESAFEPSNHESDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK

Nucleotide

• Length: 549 bp

>T97837 NZ_CP027310:c944320-943772 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGTTTTTGAATCCGCATTTGAGCCGTCTAATCATGAGAGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAGTCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTTGTAGCCGGAATGTTTG
TATCATTTCTTATTGCTCATGAAGGAAAGCCGCCAGTTGAAGCAATCGTTGCATTACTGGGAACAAGTACAATTAGTATT
GTTGGTTTGGTTGGCTTCGTTGTTAGTGGATTGTTCAAATCTAGAAAAGATGGCGATAAAGAAAAATAA

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17298.80 Da
• Isoelectric Point: 8.4143

>AT97837 WP_000287252.1 NZ_CP027310:c944816-944343 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Nucleotide

• Length: 474 bp

>AT97837 NZ_CP027310:c944816-944343 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGATTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCTCAAGCAGAGAGCATTATAGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A839B6W4