Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 584891..585723 Replicon chromosome
Accession NZ_CP027310
Organism Escherichia coli strain 2014C-4135

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag C6N22_RS02925 Protein ID WP_000854753.1
Coordinates 584891..585265 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag C6N22_RS02930 Protein ID WP_001315620.1
Coordinates 585355..585723 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N22_RS02880 580106..581212 + 1107 WP_001315214.1 N-acetylneuraminate epimerase -
C6N22_RS02885 581277..582257 + 981 WP_001295601.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
C6N22_RS02890 582265..582915 - 651 WP_001037966.1 HNH endonuclease -
C6N22_RS26520 583960..584112 - 153 WP_001280445.1 hypothetical protein -
C6N22_RS02915 584197..584394 - 198 WP_000839281.1 DUF957 domain-containing protein -
C6N22_RS02920 584406..584894 - 489 WP_000777547.1 hypothetical protein -
C6N22_RS02925 584891..585265 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
C6N22_RS02930 585355..585723 - 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6N22_RS02935 585886..586107 - 222 WP_000692345.1 DUF987 domain-containing protein -
C6N22_RS02940 586170..586646 - 477 WP_001560709.1 RadC family protein -
C6N22_RS02945 586662..587147 - 486 WP_000849588.1 antirestriction protein -
C6N22_RS02950 587202..588020 - 819 WP_001234620.1 DUF945 domain-containing protein -
C6N22_RS02960 588120..588353 - 234 WP_001119729.1 DUF905 family protein -
C6N22_RS02965 588432..588887 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T97835 WP_000854753.1 NZ_CP027310:c585265-584891 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T97835 NZ_CP027310:c585265-584891 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT97835 WP_001315620.1 NZ_CP027310:c585723-585355 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT97835 NZ_CP027310:c585723-585355 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References