Detailed information of TA system TA097801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5843992..5844517
• Replicon: chromosome
• Accession: NZ_CP027306
• Organism: Streptomyces atratus strain SCSIO_ZH16

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C5746_RS26945
• Protein ID: WP_114246427.1
• Coordinates: 5843992..5844255 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: C5746_RS26950
• Protein ID: WP_114246428.1
• Coordinates: 5844248..5844517 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5746_RS26925	5839816..5840556	+	741	WP_114246424.1	ROK family protein	-
C5746_RS26930	5840641..5841246	-	606	WP_198676859.1	hypothetical protein	-
C5746_RS26935	5841488..5842576	+	1089	WP_093896813.1	redox-regulated ATPase YchF	-
C5746_RS26940	5842700..5843887	-	1188	WP_114246426.1	hypothetical protein	-
C5746_RS26945	5843992..5844255	-	264	WP_114246427.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C5746_RS26950	5844248..5844517	-	270	WP_114246428.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
C5746_RS26955	5844808..5845542	-	735	WP_198676860.1	carbonic anhydrase	-
C5746_RS26960	5846448..5847194	+	747	WP_114246430.1	IPT/TIG domain-containing protein	-
C5746_RS26965	5847493..5848755	+	1263	WP_198677150.1	IPT/TIG domain-containing protein	-
C5746_RS26970	5848896..5849396	+	501	WP_114246431.1	levansucrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-57)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10096.54 Da
• Isoelectric Point: 9.6922

>T97801 WP_114246427.1 NZ_CP027306:c5844255-5843992 [Streptomyces atratus]
VSEYRTVFRPEAQAELRKIPRDVALRILAKLTELERDPLDFSTTALVSQPDRRRLRVGDYRIVYTIDNGELVVRVVHVGH
RSTIHDT

Nucleotide

• Length: 264 bp

>T97801 NZ_CP027306:c5844255-5843992 [Streptomyces atratus]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCCCAAGCGGAGCTGCGAAAGATTCCCCGCGACGTGGCACTCCGCAT
TCTGGCAAAGCTGACCGAGCTGGAAAGGGACCCACTCGACTTCAGCACCACCGCACTCGTCTCTCAGCCCGATCGCCGTC
GCCTACGCGTGGGTGACTACCGCATCGTCTACACGATCGACAACGGAGAGCTGGTGGTGCGGGTTGTGCACGTCGGGCAT
CGCTCCACCATCCATGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10288.71 Da
• Isoelectric Point: 4.7746

>AT97801 WP_114246428.1 NZ_CP027306:c5844517-5844248 [Streptomyces atratus]
MTHPLPVESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIETLRKYQEWEEREINRIIDERMANPAVGIPLEDI
MRETLARSE

Nucleotide

• Length: 270 bp

>AT97801 NZ_CP027306:c5844517-5844248 [Streptomyces atratus]
ATGACGCACCCACTGCCCGTAGAGTCCATCCGCGACGTGCGCGCACACCTGGCCGAGGTCGTGGAGCGCGCTGATCGCGA
CGACGTGCCCACGGTGATCACACGCCGAGGCAAGGAAGTCGCCGCGGTGGTGTCCATCGAGACCCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAATCGAATCATCGACGAGCGAATGGCGAACCCCGCGGTCGGCATTCCCCTTGAGGACATC
ATGAGGGAGACCCTGGCGCGCAGTGAGTGA