Detailed information of TA system TA097800

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 3525360..3525925
• Replicon: chromosome
• Accession: NZ_CP027306
• Organism: Streptomyces atratus strain SCSIO_ZH16

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: C5746_RS15985
• Protein ID: WP_114244769.1
• Coordinates: 3525360..3525728 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: C5746_RS15990
• Protein ID: WP_114249050.1
• Coordinates: 3525728..3525925 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5746_RS15970	3520804..3522420	-	1617	WP_114244767.1	WxL domain-containing protein	-
C5746_RS15975	3522801..3523301	+	501	WP_114249049.1	hypothetical protein	-
C5746_RS15980	3523414..3525195	-	1782	WP_114244768.1	DEAD/DEAH box helicase	-
C5746_RS15985	3525360..3525728	-	369	WP_114244769.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
C5746_RS15990	3525728..3525925	-	198	WP_114249050.1	Arc family DNA-binding protein	Antitoxin
C5746_RS15995	3525958..3527457	-	1500	WP_114244770.1	MFS transporter	-
C5746_RS16005	3527786..3528331	-	546	WP_114244771.1	hypothetical protein	-
C5746_RS16010	3528663..3529298	-	636	WP_198676779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (12-117)

Antitoxin

• Arc-like DNA binding domain (5-33)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13572.51 Da
• Isoelectric Point: 4.8616

>T97800 WP_114244769.1 NZ_CP027306:c3525728-3525360 [Streptomyces atratus]
MKYLTLPELLNLAERLGAAEVRDYGLLDSALARPQASVFGQDAYPDVWQKAAALMESLARNHALVDGNKRIAWYATWVFL
HINGHRLSADFDVDEAEKFVLDVCQGALDMPRIAERLPGFAA

Nucleotide

• Length: 369 bp

>T97800 NZ_CP027306:c3525728-3525360 [Streptomyces atratus]
ATGAAGTACCTGACACTTCCCGAGCTGCTCAACCTTGCCGAGCGCCTCGGGGCCGCCGAGGTGCGCGACTACGGGCTGCT
CGATTCGGCGCTCGCCCGCCCGCAGGCGAGCGTGTTCGGCCAGGACGCCTATCCGGACGTGTGGCAGAAGGCCGCGGCGC
TCATGGAGTCCCTGGCGCGCAATCATGCGCTCGTCGACGGAAACAAGCGCATTGCCTGGTATGCCACCTGGGTCTTCCTG
CACATCAACGGGCATCGCCTGAGCGCGGACTTCGATGTCGATGAGGCCGAGAAGTTCGTGCTGGACGTGTGCCAGGGGGC
CCTCGACATGCCCAGGATCGCGGAACGGCTCCCCGGGTTCGCCGCGTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7338.18 Da
• Isoelectric Point: 5.0632

>AT97800 WP_114249050.1 NZ_CP027306:c3525925-3525728 [Streptomyces atratus]
MAGLNLRFTEEELDALRARAESEGRSMQSFAHDAVITAINEHSRLFNEAADHVLKVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT97800 NZ_CP027306:c3525925-3525728 [Streptomyces atratus]
ATGGCTGGTCTGAATCTGCGGTTCACCGAAGAAGAGCTGGACGCACTGCGTGCACGCGCCGAGTCGGAGGGGCGGAGCAT
GCAGTCGTTCGCCCACGACGCGGTGATCACCGCCATAAACGAACACTCGCGCCTCTTCAACGAGGCCGCGGACCACGTGC
TGAAGGTGAGTGAGGAGCTCAACCGGAGGCTCGCCTGA