Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 3347941..3348553 | Replicon | chromosome |
| Accession | NC_000911 | ||
| Organism | Synechocystis sp. PCC 6803 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | SGL_RS17355 | Protein ID | WP_010874170.1 |
| Coordinates | 3348191..3348553 (+) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | SGL_RS17350 | Protein ID | WP_010874169.1 |
| Coordinates | 3347941..3348201 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SGL_RS17335 (sll0623) | 3345027..3345815 | - | 789 | WP_010874166.1 | hypothetical protein | - |
| SGL_RS17340 (sll0622) | 3345861..3346817 | - | 957 | WP_010874167.1 | quinolinate synthase NadA | - |
| SGL_RS17345 (sll0621) | 3346910..3347656 | - | 747 | WP_010874168.1 | cytochrome c biogenesis protein CcdA | - |
| SGL_RS17350 (ssr1114) | 3347941..3348201 | + | 261 | WP_010874169.1 | hypothetical protein | Antitoxin |
| SGL_RS17355 (slr0664) | 3348191..3348553 | + | 363 | WP_010874170.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| SGL_RS17360 (slr0665) | 3348690..3351296 | + | 2607 | WP_010874171.1 | bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase | - |
| SGL_RS17365 (slr0666) | 3351526..3352353 | + | 828 | WP_010874172.1 | hypothetical protein | - |
| SGL_RS17370 (slr0667) | 3352682..3353203 | + | 522 | WP_010874173.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13679.59 Da Isoelectric Point: 8.2767
>T978 WP_010874170.1 NC_000911:3348191-3348553 [Synechocystis sp. PCC 6803]
MSNNLHLVNIDFTPEYRRSLKYLAKKYRNIRSDVQPIIEALQKGVISGDRLAGFGSDIYVYKLRIKNSNIQKGKSSGYRL
IYLLESENSILLLTIYSKAEQEDIAASDINSILGEYSIED
MSNNLHLVNIDFTPEYRRSLKYLAKKYRNIRSDVQPIIEALQKGVISGDRLAGFGSDIYVYKLRIKNSNIQKGKSSGYRL
IYLLESENSILLLTIYSKAEQEDIAASDINSILGEYSIED
Download Length: 363 bp
>T978 NC_000911:3348191-3348553 [Synechocystis sp. PCC 6803]
ATGTCGAATAATCTCCATTTAGTCAATATCGACTTCACCCCCGAATATAGGAGAAGTTTAAAATATTTAGCCAAGAAATA
TCGAAATATTCGTTCTGATGTTCAGCCCATTATTGAGGCTTTGCAAAAAGGCGTCATTAGTGGTGATCGCCTGGCAGGGT
TTGGCTCTGATATTTACGTCTATAAGCTTAGAATTAAGAATAGTAATATTCAGAAAGGGAAAAGTTCTGGCTACCGATTA
ATTTATTTACTCGAATCAGAAAACAGTATTTTGTTGTTAACCATTTACAGTAAAGCTGAACAAGAAGATATTGCCGCTAG
TGACATTAATTCAATTTTAGGGGAGTACTCCATAGAAGACTAA
ATGTCGAATAATCTCCATTTAGTCAATATCGACTTCACCCCCGAATATAGGAGAAGTTTAAAATATTTAGCCAAGAAATA
TCGAAATATTCGTTCTGATGTTCAGCCCATTATTGAGGCTTTGCAAAAAGGCGTCATTAGTGGTGATCGCCTGGCAGGGT
TTGGCTCTGATATTTACGTCTATAAGCTTAGAATTAAGAATAGTAATATTCAGAAAGGGAAAAGTTCTGGCTACCGATTA
ATTTATTTACTCGAATCAGAAAACAGTATTTTGTTGTTAACCATTTACAGTAAAGCTGAACAAGAAGATATTGCCGCTAG
TGACATTAATTCAATTTTAGGGGAGTACTCCATAGAAGACTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9909.29 Da Isoelectric Point: 4.3705
>AT978 WP_010874169.1 NC_000911:3347941-3348201 [Synechocystis sp. PCC 6803]
MMRAFEVMATVKDSKQLLLDSDLHWNTSRVKVIILESDELASKGSEFDPDDTPVEEIKVSLRKALEEYKQGKRIPVENMW
EGIDVE
MMRAFEVMATVKDSKQLLLDSDLHWNTSRVKVIILESDELASKGSEFDPDDTPVEEIKVSLRKALEEYKQGKRIPVENMW
EGIDVE
Download Length: 261 bp
>AT978 NC_000911:3347941-3348201 [Synechocystis sp. PCC 6803]
ATGATGAGAGCTTTTGAGGTAATGGCCACAGTTAAAGATTCCAAACAATTGCTCTTGGATAGTGATTTGCATTGGAATAC
CAGCCGAGTCAAGGTGATTATTTTGGAATCAGATGAATTGGCATCAAAAGGAAGTGAGTTTGATCCTGATGACACGCCTG
TCGAAGAAATTAAGGTGAGTTTGAGGAAGGCATTAGAGGAATATAAACAAGGAAAAAGAATTCCAGTAGAAAATATGTGG
GAGGGAATTGATGTCGAATAA
ATGATGAGAGCTTTTGAGGTAATGGCCACAGTTAAAGATTCCAAACAATTGCTCTTGGATAGTGATTTGCATTGGAATAC
CAGCCGAGTCAAGGTGATTATTTTGGAATCAGATGAATTGGCATCAAAAGGAAGTGAGTTTGATCCTGATGACACGCCTG
TCGAAGAAATTAAGGTGAGTTTGAGGAAGGCATTAGAGGAATATAAACAAGGAAAAAGAATTCCAGTAGAAAATATGTGG
GAGGGAATTGATGTCGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Degang Ning et al. (2011) The proteolytic activation of the relNEs (ssr1114/slr0664) toxin-antitoxin system by both proteases Lons and ClpP2s/Xs of Synechocystis sp. PCC 6803. Current Microbiology 63(5):496-502. [PubMed:21909782]