Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4941855..4943438 Replicon chromosome
Accession NZ_CP027300
Organism Serratia marcescens strain SGAir0764

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C1N78_RS23690 Protein ID WP_110147612.1
Coordinates 4942110..4943438 (+) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C1N78_RS23685 Protein ID WP_110147515.1
Coordinates 4941855..4942106 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N78_RS23660 4937396..4937653 + 258 WP_025304809.1 cloacin -
C1N78_RS23665 4937772..4938146 - 375 Protein_4592 group II intron reverse transcriptase/maturase -
C1N78_RS23670 4938864..4939736 + 873 WP_110147513.1 hypothetical protein -
C1N78_RS25225 4939739..4940353 + 615 WP_148666832.1 hypothetical protein -
C1N78_RS23675 4940548..4941144 + 597 WP_110147514.1 hypothetical protein -
C1N78_RS25425 4941178..4941342 - 165 WP_199561529.1 helix-turn-helix domain-containing protein -
C1N78_RS25430 4941303..4941519 - 217 Protein_4597 recombinase family protein -
C1N78_RS23685 4941855..4942106 + 252 WP_110147515.1 helix-turn-helix domain-containing protein Antitoxin
C1N78_RS23690 4942110..4943438 + 1329 WP_110147612.1 type II toxin-antitoxin system HipA family toxin Toxin
C1N78_RS23695 4944540..4945853 + 1314 WP_110147516.1 hypothetical protein -
C1N78_RS23700 4945840..4946598 - 759 WP_110147517.1 hypothetical protein -
C1N78_RS23705 4947255..4948361 - 1107 WP_110147518.1 TniQ family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4933189..4955173 21984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 49236.59 Da        Isoelectric Point: 5.3440

>T97796 WP_110147612.1 NZ_CP027300:4942110-4943438 [Serratia marcescens]
MRTQVLSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQRGRIIGSAVYNFFSNLLPDSEAIIDRMQVR
FKVKTDHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMDEDADFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHNNIDLRESCENEWLCLCIAREFGFPVTNAELAMFGQRKVLVVERFDRKWS
SSGAWLLRLPQEDCCQALGIAPALKYESDGGPGIEAIMKLLLGSRTTLEDRETFFKSQILFWMLAAIDGHGKNFSIFIEP
GTSFRLTPLYDVMSAFPIFEARGIEVKKAKMAMALQGKNKQYNFSMIQPRHFISTAAKVGFSPKAATQLMVAMAEKADAV
IAAILPQLPEDFPEHISKAIFAGLSKQADKIKRWATSQTNQD

Download         Length: 1329 bp

>T97796 NZ_CP027300:4942110-4943438 [Serratia marcescens]
ATGAGGACTCAGGTACTTTCTGTCGCCATGAATGGTGATTTGGTTGGCAAACTAACCAAAAATACTGATGGTGGGATGTC
ATTTCAATACGCAGAAGAATGGTTGGCAGAACCAGGGGCGCGGGCAATCTCATTATCACTTCCTTTGCAACGTGGACGCA
TAATCGGTAGCGCGGTTTACAATTTCTTCAGCAACCTTTTGCCTGATTCTGAGGCGATTATTGATAGAATGCAGGTTCGT
TTTAAGGTAAAAACAGACCATCCTTTTGATCTGCTCGCCGCTGTGGGTCGTGACTGTGTTGGCGCAATCCAGTTATATTC
TCCTGATACTGAAATTCCATCGGTGATGGAAACTCATGCCGAACCTCTAAATGAAAACCAAATCGAAGAACTTTTAGACG
GCTATCAAACCGCACCTCTTGGAATGGACGAGGATGCGGACTTTCGGATCTCCCTCGCAGGGGCTCAAGAGAAAACAGCA
TTACTTTGGTATCAAGACTGTTGGCAGCGGCCACAAGGCAGTACCCCGACAAGTCATATTTTCAAATTACCCATAGGCCT
GATTGAACACAATAACATTGATCTGCGCGAAAGCTGTGAAAACGAATGGCTATGCTTATGTATAGCAAGAGAATTTGGAT
TTCCAGTCACCAACGCTGAATTGGCAATGTTCGGTCAGAGAAAGGTACTGGTCGTAGAACGTTTTGACCGAAAATGGTCT
TCATCTGGAGCCTGGCTATTACGCCTACCTCAGGAGGACTGTTGTCAAGCTCTGGGTATTGCGCCTGCCTTAAAATATGA
GTCTGACGGCGGGCCTGGTATTGAAGCCATCATGAAGTTGCTTTTGGGATCACGAACAACGCTCGAAGATAGAGAGACTT
TCTTTAAATCACAAATCCTGTTCTGGATGCTGGCCGCAATAGATGGACATGGGAAAAATTTCTCTATCTTCATTGAGCCT
GGAACATCTTTCCGTTTAACGCCCTTGTACGATGTTATGTCTGCTTTTCCAATTTTTGAGGCGCGAGGGATAGAGGTAAA
AAAAGCCAAAATGGCTATGGCATTACAAGGAAAAAACAAGCAGTACAATTTTTCCATGATCCAACCGCGTCATTTTATCA
GTACCGCTGCAAAGGTCGGTTTTTCTCCGAAAGCCGCAACGCAGCTAATGGTTGCAATGGCCGAAAAGGCTGATGCGGTT
ATAGCTGCCATATTACCTCAGCTACCTGAAGATTTTCCTGAGCATATTAGCAAAGCCATATTTGCTGGGTTATCAAAACA
AGCTGATAAAATTAAAAGATGGGCCACCTCACAAACTAACCAAGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9460.94 Da        Isoelectric Point: 10.4253

>AT97796 WP_110147515.1 NZ_CP027300:4941855-4942106 [Serratia marcescens]
MKITTPKMLAAAMREQRKKNKLTQAQAADQVGLRQATVSEFENTPESTKLETFFKILASLDLELHVVKRGSTLNEGKVWN
KEW

Download         Length: 252 bp

>AT97796 NZ_CP027300:4941855-4942106 [Serratia marcescens]
ATGAAGATTACAACACCAAAGATGCTTGCTGCTGCAATGCGTGAGCAACGCAAAAAAAACAAATTAACCCAAGCGCAAGC
CGCAGATCAAGTCGGTCTCAGGCAAGCGACAGTTTCTGAGTTTGAGAACACACCTGAATCAACGAAACTCGAAACATTTT
TCAAAATTCTTGCCTCTTTGGATCTGGAATTACATGTAGTAAAGCGGGGCTCCACACTAAATGAAGGTAAGGTATGGAAC
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References