Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3782149..3782805 Replicon chromosome
Accession NZ_CP027300
Organism Serratia marcescens strain SGAir0764

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag C1N78_RS18170 Protein ID WP_016926704.1
Coordinates 3782149..3782538 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag C1N78_RS18175 Protein ID WP_004941563.1
Coordinates 3782542..3782805 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N78_RS18155 3778617..3780047 + 1431 WP_016926706.1 multidrug transporter subunit MdtD -
C1N78_RS18160 3780044..3781426 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
C1N78_RS18165 3781426..3782142 + 717 WP_004941568.1 two-component system response regulator BaeR -
C1N78_RS18170 3782149..3782538 - 390 WP_016926704.1 type II toxin-antitoxin system VapC family toxin Toxin
C1N78_RS18175 3782542..3782805 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
C1N78_RS18180 3783144..3783482 + 339 WP_016926703.1 YegP family protein -
C1N78_RS18185 3783661..3785013 + 1353 WP_028127781.1 tRNA 5-hydroxyuridine modification protein YegQ -
C1N78_RS18190 3785481..3786386 + 906 WP_016926701.1 lipid kinase YegS -
C1N78_RS18195 3786555..3787769 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14342.61 Da        Isoelectric Point: 7.8794

>T97792 WP_016926704.1 NZ_CP027300:c3782538-3782149 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T97792 NZ_CP027300:c3782538-3782149 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCTGCAGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGTTGCTACGGTGAAATG
CGGGCAACCATGGAGAGAAAGGGCAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGTTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT97792 WP_004941563.1 NZ_CP027300:c3782805-3782542 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT97792 NZ_CP027300:c3782805-3782542 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGTATTATCGCCCAAACGCCGGTGCCGCAAGAATTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTGGCAGACCGC
GATCCGTTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References