Detailed information of TA system TA097782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1729329..1729854
• Replicon: chromosome
• Accession: NZ_CP027300
• Organism: Serratia marcescens strain SGAir0764

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8G2G914
• Locus tag: C1N78_RS08355
• Protein ID: WP_016928357.1
• Coordinates: 1729329..1729613 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A542C2P2
• Locus tag: C1N78_RS08360
• Protein ID: WP_016928356.1
• Coordinates: 1729603..1729854 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1N78_RS08330	1724589..1725722	+	1134	WP_033640832.1	putrescine ABC transporter ATP-binding subunit PotG	-
C1N78_RS08335	1725747..1726709	+	963	WP_016928361.1	putrescine ABC transporter permease PotH	-
C1N78_RS08340	1726706..1727551	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
C1N78_RS08345	1727656..1728135	+	480	WP_028127974.1	YbjO family protein	-
C1N78_RS08350	1728205..1729332	+	1128	WP_110146837.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
C1N78_RS08355	1729329..1729613	-	285	WP_016928357.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C1N78_RS08360	1729603..1729854	-	252	WP_016928356.1	prevent-host-death protein	Antitoxin
C1N78_RS08365	1729956..1730690	-	735	WP_016928355.1	arginine ABC transporter substrate-binding protein	-
C1N78_RS08370	1730890..1731558	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
C1N78_RS08375	1731558..1732274	-	717	WP_110146838.1	arginine ABC transporter permease ArtQ	-
C1N78_RS08380	1732284..1733015	-	732	WP_004928409.1	arginine ABC transporter substrate-binding protein	-
C1N78_RS08385	1733048..1733776	-	729	WP_110147567.1	arginine ABC transporter ATP-binding protein ArtP	-
C1N78_RS08390	1734040..1734582	-	543	WP_079449454.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10775.89 Da
• Isoelectric Point: 10.6941

>T97782 WP_016928357.1 NZ_CP027300:c1729613-1729329 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPAIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRIMETEIVVLVLSVGK
RERSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T97782 NZ_CP027300:c1729613-1729329 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACACGCACTGAAGGAATTTAAAAAACTGTCCCCGGCGATCCGGGAACAGTTCAA
AAAAAAGCTGGCATCCGTGTTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCTGATTGCTACAAAATCA
AACTCAGAGCCTCAGGCTTTCGTTTGGTGTATCGCATCATGGAGACGGAGATCGTGGTTCTGGTCCTTTCTGTGGGCAAA
CGCGAACGTTCAGCGGCTTACACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT97782 WP_016928356.1 NZ_CP027300:c1729854-1729603 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDLELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT97782 NZ_CP027300:c1729854-1729603 [Serratia marcescens]
ATGACGGTTCAACCCATTCTCGCCGACTCCGCAGTTAGCATCAGCGATTTTAAAAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAACCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCTCCGGAAACCTGGGAGGCGA
TCGCGGAGTACCTGGAAGATCTCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A542C2P2