Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1127231..1127852 Replicon chromosome
Accession NZ_CP027300
Organism Serratia marcescens strain SGAir0764

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag C1N78_RS05410 Protein ID WP_004940313.1
Coordinates 1127231..1127434 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag C1N78_RS05415 Protein ID WP_004940312.1
Coordinates 1127484..1127852 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1N78_RS05380 1122932..1123270 + 339 WP_049299676.1 P-II family nitrogen regulator -
C1N78_RS05385 1123306..1124592 + 1287 WP_004940322.1 ammonium transporter AmtB -
C1N78_RS05390 1124683..1125546 - 864 WP_016928847.1 acyl-CoA thioesterase II -
C1N78_RS05395 1125777..1126268 + 492 WP_016928846.1 YbaY family lipoprotein -
C1N78_RS05400 1126333..1126647 - 315 WP_004940317.1 MGMT family protein -
C1N78_RS05410 1127231..1127434 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
C1N78_RS05415 1127484..1127852 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
C1N78_RS05420 1128011..1128364 - 354 WP_016928845.1 hypothetical protein -
C1N78_RS05425 1128769..1129482 + 714 WP_110146728.1 ABC transporter ATP-binding protein -
C1N78_RS05430 1129479..1130336 + 858 WP_004940309.1 metal ABC transporter permease -
C1N78_RS05435 1130362..1131240 + 879 WP_049299673.1 metal ABC transporter substrate-binding protein -
C1N78_RS05440 1131347..1131487 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
C1N78_RS05445 1131500..1131754 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T97781 WP_004940313.1 NZ_CP027300:c1127434-1127231 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T97781 NZ_CP027300:c1127434-1127231 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT97781 WP_004940312.1 NZ_CP027300:c1127852-1127484 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT97781 NZ_CP027300:c1127852-1127484 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGGCACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References