Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3038974..3039592 Replicon chromosome
Accession NZ_CP027255
Organism Escherichia coli strain EC11

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C6C13_RS15545 Protein ID WP_001291435.1
Coordinates 3038974..3039192 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag C6C13_RS15550 Protein ID WP_106022965.1
Coordinates 3039218..3039592 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6C13_RS15510 3034264..3034836 + 573 WP_000779826.1 lipoprotein -
C6C13_RS15515 3034867..3035178 - 312 WP_000409911.1 MGMT family protein -
C6C13_RS15525 3035557..3035910 + 354 WP_000878141.1 DUF1428 family protein -
C6C13_RS15530 3035952..3037502 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C6C13_RS15535 3037666..3038136 - 471 WP_000136192.1 YlaC family protein -
C6C13_RS15540 3038252..3038803 - 552 WP_047622526.1 maltose O-acetyltransferase -
C6C13_RS15545 3038974..3039192 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
C6C13_RS15550 3039218..3039592 - 375 WP_106022965.1 Hha toxicity modulator TomB Antitoxin
C6C13_RS15555 3040138..3043287 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
C6C13_RS15560 3043310..3044503 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T97755 WP_001291435.1 NZ_CP027255:c3039192-3038974 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T97755 NZ_CP027255:c3039192-3038974 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14504.34 Da        Isoelectric Point: 4.5917

>AT97755 WP_106022965.1 NZ_CP027255:c3039592-3039218 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFCCFVNATKENPASLSC

Download         Length: 375 bp

>AT97755 NZ_CP027255:c3039592-3039218 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCTGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References