Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 531134..531969 Replicon chromosome
Accession NZ_CP027255
Organism Escherichia coli strain EC11

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2H4TUZ7
Locus tag C6C13_RS02615 Protein ID WP_000854744.1
Coordinates 531592..531969 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3J1F1Y9
Locus tag C6C13_RS02610 Protein ID WP_063104706.1
Coordinates 531134..531502 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6C13_RS02570 526372..526854 + 483 WP_000649890.1 hypothetical protein -
C6C13_RS02585 527213..528031 + 819 WP_001234708.1 DUF945 domain-containing protein -
C6C13_RS26640 528364..529065 - 702 WP_137432245.1 hypothetical protein -
C6C13_RS02595 529458..529922 + 465 WP_106022912.1 antirestriction protein -
C6C13_RS02600 529937..530413 + 477 WP_001186727.1 RadC family protein -
C6C13_RS02605 530482..531084 + 603 WP_000692332.1 hypothetical protein -
C6C13_RS02610 531134..531502 + 369 WP_063104706.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6C13_RS02615 531592..531969 + 378 WP_000854744.1 TA system toxin CbtA family protein Toxin
C6C13_RS02620 531966..532454 + 489 WP_000777668.1 hypothetical protein -
C6C13_RS02625 532466..532663 + 198 WP_000772034.1 DUF957 domain-containing protein -
C6C13_RS02630 532748..533593 + 846 WP_000065753.1 DUF4942 domain-containing protein -
C6C13_RS02640 534328..536580 + 2253 WP_000491433.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14138.13 Da        Isoelectric Point: 8.5163

>T97745 WP_000854744.1 NZ_CP027255:531592-531969 [Escherichia coli]
MKTLPDTHVREASRCSSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACSCSQLINSIDILRARRATGLMTRSHYRTVNNITRGKHPEAKR

Download         Length: 378 bp

>T97745 NZ_CP027255:531592-531969 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCTCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTAAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTAGCTGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCAACAGGTCTGATGACCCGCAG
CCACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13571.25 Da        Isoelectric Point: 6.2044

>AT97745 WP_063104706.1 NZ_CP027255:531134-531502 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPCHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT97745 NZ_CP027255:531134-531502 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCTGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCAGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H4TUZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A3J1F1Y9

References