Detailed information of TA system TA097743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2588684..2589363
• Replicon: chromosome
• Accession: NZ_CP027254
• Organism: Acinetobacter pittii strain WCHAP100020

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: C6N17_RS13160
• Protein ID: WP_000838146.1
• Coordinates: 2589181..2589363 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A915WMT7
• Locus tag: C6N17_RS13155
• Protein ID: WP_023187967.1
• Coordinates: 2588684..2589088 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N17_RS13120	2584192..2585355	-	1164	WP_002045824.1	glutathione-dependent formaldehyde dehydrogenase	-
C6N17_RS13125	2585797..2586213	+	417	WP_005070343.1	hypothetical protein	-
C6N17_RS13130	2586221..2587036	+	816	Protein_2436	IS30 family transposase	-
C6N17_RS13135	2587037..2587291	+	255	WP_108700409.1	IS30 family transposase	-
C6N17_RS13140	2587282..2587509	-	228	WP_171492026.1	hypothetical protein	-
C6N17_RS13145	2587640..2587903	-	264	WP_001275792.1	hypothetical protein	-
C6N17_RS13150	2587905..2588585	-	681	WP_000721572.1	hypothetical protein	-
C6N17_RS13155	2588684..2589088	-	405	WP_023187967.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C6N17_RS13160	2589181..2589363	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
C6N17_RS13165	2589689..2590204	-	516	WP_025464105.1	hypothetical protein	-
C6N17_RS13170	2590275..2591192	-	918	WP_106389260.1	hypothetical protein	-
C6N17_RS13175	2591245..2592573	-	1329	WP_023187966.1	hypothetical protein	-
C6N17_RS13180	2592573..2592926	-	354	WP_002121621.1	hypothetical protein	-
C6N17_RS13185	2592995..2593393	-	399	WP_002121567.1	hypothetical protein	-
C6N17_RS13190	2593395..2593763	-	369	WP_000539743.1	hypothetical protein	-
C6N17_RS13195	2593735..2594139	-	405	WP_002121581.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2580067..2614128	34061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T97743 WP_000838146.1 NZ_CP027254:c2589363-2589181 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T97743 NZ_CP027254:c2589363-2589181 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14663.74 Da
• Isoelectric Point: 4.4328

>AT97743 WP_023187967.1 NZ_CP027254:c2589088-2588684 [Acinetobacter pittii]
MLYLIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT97743 NZ_CP027254:c2589088-2588684 [Acinetobacter pittii]
ATGTTATATCTAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7