Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2455796..2456472 Replicon chromosome
Accession NZ_CP027254
Organism Acinetobacter pittii strain WCHAP100020

Toxin (Protein)


Gene name hicA Uniprot ID A0A829SCE7
Locus tag C6N17_RS12360 Protein ID WP_031968589.1
Coordinates 2456290..2456472 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A829S8Y7
Locus tag C6N17_RS12355 Protein ID WP_031968590.1
Coordinates 2455796..2456200 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N17_RS12345 2451099..2455085 - 3987 WP_106389252.1 tape measure protein -
C6N17_RS12350 2455182..2455700 - 519 WP_032023512.1 DUF4468 domain-containing protein -
C6N17_RS12355 2455796..2456200 - 405 WP_031968590.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C6N17_RS12360 2456290..2456472 - 183 WP_031968589.1 type II toxin-antitoxin system HicA family toxin Toxin
C6N17_RS12365 2456541..2456747 - 207 WP_170825808.1 hypothetical protein -
C6N17_RS12370 2456804..2457337 - 534 WP_031968588.1 hypothetical protein -
C6N17_RS12375 2457383..2458312 - 930 WP_057104459.1 hypothetical protein -
C6N17_RS12380 2458420..2458638 - 219 WP_031968585.1 hypothetical protein -
C6N17_RS12385 2458640..2459038 - 399 WP_031968584.1 hypothetical protein -
C6N17_RS12390 2459040..2459408 - 369 WP_031968583.1 hypothetical protein -
C6N17_RS12395 2459380..2459784 - 405 WP_031968582.1 hypothetical protein -
C6N17_RS12400 2459965..2460333 - 369 WP_086378109.1 glutamate 5-kinase -
C6N17_RS12405 2460337..2460726 - 390 WP_057073526.1 hypothetical protein -
C6N17_RS12410 2460731..2461396 - 666 WP_106389253.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2425699..2489171 63472


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6690.86 Da        Isoelectric Point: 10.7364

>T97742 WP_031968589.1 NZ_CP027254:c2456472-2456290 [Acinetobacter pittii]
VKSLDLIKMIEADGWYQVRVTGSHHHFKHPTKKGLVTVPHPKKDLPSGTVKSILKQAGLH

Download         Length: 183 bp

>T97742 NZ_CP027254:c2456472-2456290 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATCAAGTTAGGGTTACAGGAAGTCATCATCACTT
CAAACACCCTACTAAGAAGGGACTGGTTACAGTTCCACATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAAAGCATTT
TGAAACAAGCAGGTCTTCATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.73 Da        Isoelectric Point: 4.3246

>AT97742 WP_031968590.1 NZ_CP027254:c2456200-2455796 [Acinetobacter pittii]
MLYPIAIEMGSDTEAFGVIVPDIPGCHSAGDTLEEALDNIKEAIAGHLEILAEDGEEIPLASSVRKFMDLPEYDGMVWFV
TEVDLGRYLGTPEKINVSLPSRLIRKIDDSVGKDKQYKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT97742 NZ_CP027254:c2456200-2455796 [Acinetobacter pittii]
ATGTTATATCCGATTGCAATTGAAATGGGATCAGATACCGAGGCATTCGGTGTCATCGTTCCTGATATTCCCGGTTGCCA
CAGCGCCGGTGATACCCTCGAAGAAGCTCTCGATAATATTAAAGAAGCGATTGCAGGGCATTTAGAGATTCTTGCTGAAG
ATGGTGAAGAGATTCCTTTAGCTTCATCTGTAAGAAAATTTATGGATCTTCCTGAATATGATGGAATGGTTTGGTTCGTA
ACTGAGGTTGATTTAGGTCGTTATCTTGGAACCCCTGAAAAAATCAACGTATCTTTGCCTAGTCGTTTGATTCGTAAGAT
TGATGATAGTGTGGGTAAAGATAAGCAGTATAAAACCCGATCTGCATTTTTGGCTGCTGGTGCTGAAAAGCTGCTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829SCE7

Antitoxin

Source ID Structure
AlphaFold DB A0A829S8Y7

References