Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2274..2802 Replicon plasmid pOXA58_100020
Accession NZ_CP027253
Organism Acinetobacter pittii strain WCHAP100020

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag C6N17_RS00455 Protein ID WP_000221358.1
Coordinates 2274..2567 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag C6N17_RS00460 Protein ID WP_000246755.1
Coordinates 2557..2802 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N17_RS00440 1..939 + 939 WP_002046604.1 replication initiation protein RepM -
C6N17_RS00445 1358..2062 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
C6N17_RS00455 2274..2567 - 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6N17_RS00460 2557..2802 - 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C6N17_RS00465 3318..4793 + 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
C6N17_RS00470 4849..5733 + 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
C6N17_RS00475 5903..6217 - 315 WP_038350244.1 BrnA antitoxin family protein -
C6N17_RS00480 6180..6491 - 312 WP_063454728.1 BrnT family toxin -
C6N17_RS00485 6710..7315 - 606 WP_000447788.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid msr(E) / mph(E) / blaOXA-58 - 1..24018 24018
- inside IScluster/Tn msr(E) / mph(E) / blaOXA-58 - 1358..10532 9174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T97740 WP_000221358.1 NZ_CP027253:c2567-2274 [Acinetobacter pittii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T97740 NZ_CP027253:c2567-2274 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT97740 WP_000246755.1 NZ_CP027253:c2802-2557 [Acinetobacter pittii]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT97740 NZ_CP027253:c2802-2557 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References