Detailed information of TA system TA097739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2515..3064
• Replicon: plasmid p2_100020
• Accession: NZ_CP027252
• Organism: Acinetobacter pittii strain WCHAP100020

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9KJ78
• Locus tag: C6N17_RS00400
• Protein ID: WP_000176412.1
• Coordinates: 2515..2805 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9KCM7
• Locus tag: C6N17_RS00405
• Protein ID: WP_005140357.1
• Coordinates: 2789..3064 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N17_RS00385	44..610	+	567	WP_000858429.1	plasmid replication DNA-binding protein	-
C6N17_RS00390	961..1278	+	318	WP_005065053.1	hypothetical protein	-
C6N17_RS00395	1803..2324	+	522	WP_000999915.1	hypothetical protein	-
C6N17_RS19275	2321..2467	+	147	WP_000192351.1	hypothetical protein	-
C6N17_RS00400	2515..2805	-	291	WP_000176412.1	type II toxin-antitoxin system YafQ family toxin	Toxin
C6N17_RS00405	2789..3064	-	276	WP_005140357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
C6N17_RS19280	3069..3224	-	156	WP_158000192.1	hypothetical protein	-
C6N17_RS00410	3328..3552	-	225	WP_002072934.1	hypothetical protein	-
C6N17_RS00415	3701..3943	+	243	WP_001015364.1	hypothetical protein	-
C6N17_RS00420	4016..5215	-	1200	WP_002072939.1	hypothetical protein	-
C6N17_RS00425	5440..6216	-	777	WP_000191151.1	hypothetical protein	-
C6N17_RS00430	6523..7683	+	1161	WP_000179382.1	MobA/MobL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9132	9132

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (9-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11187.12 Da
• Isoelectric Point: 6.9783

>T97739 WP_000176412.1 NZ_CP027252:c2805-2515 [Acinetobacter pittii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Nucleotide

• Length: 291 bp

>T97739 NZ_CP027252:c2805-2515 [Acinetobacter pittii]
ATGACACTGACGATTAGGTACAAGAAACAATTTAAAAAAGATTTTAAACGGGTAAGCTCAAACCCAAAGCTTAAGAAAGG
ACTCTTAATTTTGAAGGATCTTATTGATGAGCATTTGGTAAAAACAGGGACTGTTCCAGATGAGTATTTACCTCATCCTT
TGATTGGTGAGTGGAAACCCCATATGGAATGCCATATTTTACCTGATTTATTATTAATTTGGGATGTGGATGAAGATAAT
AATGAGCTAATACTTGCTCGGATTGGATCTCATTCTGAACTTTTTGGATAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10290.65 Da
• Isoelectric Point: 4.6702

>AT97739 WP_005140357.1 NZ_CP027252:c3064-2789 [Acinetobacter pittii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Nucleotide

• Length: 276 bp

>AT97739 NZ_CP027252:c3064-2789 [Acinetobacter pittii]
ATGAATACTTTGGCAAAAAAAGATGAGTATGTACGTGCTAGGGTTCCAAATGAATTAAAGGTTCAAGCGGAGCGAATTCT
AAAAGAAGTGGGTTTAAATACTACAGATGCTATTCGCTTATTATTAACGCAAGTAGTAAATCGAGGTGGATTTCCTTTAG
AGTTAAGAACCCCTAACCGTACAACAATTGAGGCTATGAACTCTGTTGCAGAACCTAAAAAATTTAGTTCTGCTCAGGAA
TTGTTTACGGATTTAGAAGATGACACTGACGATTAG

Structures

Toxin

• AlphaFold DB: N9KJ78

Antitoxin

• AlphaFold DB: N9KCM7