Detailed information of TA system TA097738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2592776..2593455
• Replicon: chromosome
• Accession: NZ_CP027250
• Organism: Acinetobacter pittii strain WCHAP100004

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: C6N19_RS13790
• Protein ID: WP_000838146.1
• Coordinates: 2593273..2593455 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: C6N19_RS13785
• Protein ID: WP_000966688.1
• Coordinates: 2592776..2593180 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C6N19_RS13755	2589327..2589560	+	234	Protein_2441	hypothetical protein	-
C6N19_RS13760	2589615..2590640	+	1026	WP_004994718.1	IS30-like element ISAba125 family transposase	-
C6N19_RS13765	2590648..2591190	+	543	Protein_2443	hypothetical protein	-
C6N19_RS13770	2591335..2591496	-	162	Protein_2444	hypothetical protein	-
C6N19_RS13775	2591732..2591995	-	264	WP_001275792.1	hypothetical protein	-
C6N19_RS13780	2591997..2592677	-	681	WP_000721572.1	hypothetical protein	-
C6N19_RS13785	2592776..2593180	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C6N19_RS13790	2593273..2593455	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
C6N19_RS13795	2593781..2594296	-	516	WP_025464105.1	hypothetical protein	-
C6N19_RS13800	2594367..2595284	-	918	WP_106405915.1	hypothetical protein	-
C6N19_RS13805	2595337..2596665	-	1329	WP_023187966.1	hypothetical protein	-
C6N19_RS13810	2596665..2597018	-	354	WP_002121621.1	hypothetical protein	-
C6N19_RS13815	2597087..2597485	-	399	WP_032021503.1	hypothetical protein	-
C6N19_RS13820	2597487..2597855	-	369	WP_005135680.1	hypothetical protein	-
C6N19_RS13825	2597827..2598237	-	411	WP_005135681.1	hypothetical protein	-
C6N19_RS20555	2598248..2598418	-	171	WP_000220307.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2578528..2623136	44608
	-	flank	IS/Tn	-	-	2589630..2590640	1010

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T97738 WP_000838146.1 NZ_CP027250:c2593455-2593273 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T97738 NZ_CP027250:c2593455-2593273 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT97738 WP_000966688.1 NZ_CP027250:c2593180-2592776 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT97738 NZ_CP027250:c2593180-2592776 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6