Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 6868..7396 Replicon plasmid pOXA58_100004
Accession NZ_CP027249
Organism Acinetobacter pittii strain WCHAP100004

Toxin (Protein)


Gene name relE Uniprot ID N9N871
Locus tag C6N19_RS00565 Protein ID WP_000221358.1
Coordinates 7103..7396 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID N9NWT9
Locus tag C6N19_RS00560 Protein ID WP_000246755.1
Coordinates 6868..7113 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6N19_RS00545 3939..4643 - 705 WP_001067790.1 IS6-like element IS1008 family transposase -
C6N19_RS00550 4708..5325 + 618 Protein_2 chromate resistance protein -
C6N19_RS00555 5322..6671 + 1350 WP_001060713.1 chromate efflux transporter -
C6N19_RS00560 6868..7113 + 246 WP_000246755.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C6N19_RS00565 7103..7396 + 294 WP_000221358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6N19_RS00575 7608..8312 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
C6N19_RS00580 8510..9013 + 504 Protein_7 Tn3 family transposase -
C6N19_RS00585 9119..9979 + 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -
C6N19_RS00590 9992..10534 + 543 WP_000587837.1 AAA family ATPase -
C6N19_RS00595 11016..11207 - 192 WP_000951934.1 hypothetical protein -
C6N19_RS00600 11231..11458 + 228 WP_000248278.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / floR / sul2 / aph(3'')-Ib / aph(3')-VIb / blaPER-1 / aph(6)-Id / mph(E) / msr(E) / blaOXA-58 - 1..105591 105591
- inside IScluster/Tn aac(3)-IId - 3939..16697 12758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11292.52 Da        Isoelectric Point: 10.4753

>T97733 WP_000221358.1 NZ_CP027249:7103-7396 [Acinetobacter pittii]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Download         Length: 294 bp

>T97733 NZ_CP027249:7103-7396 [Acinetobacter pittii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9249.64 Da        Isoelectric Point: 4.3142

>AT97733 WP_000246755.1 NZ_CP027249:6868-7113 [Acinetobacter pittii]
MATVNFRIDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Download         Length: 246 bp

>AT97733 NZ_CP027249:6868-7113 [Acinetobacter pittii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACTGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A1RKP4

Antitoxin

Source ID Structure
AlphaFold DB A0A6A1RJ80

References