Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2790304..2791226 Replicon chromosome
Accession NZ_CP027225
Organism Phytobacter sp. SCO41

Toxin (Protein)


Gene name - Uniprot ID A0A348DED3
Locus tag C5523_RS13590 Protein ID WP_039079059.1
Coordinates 2790750..2791226 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A348DED2
Locus tag C5523_RS13585 Protein ID WP_071194172.1
Coordinates 2790304..2790750 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5523_RS13575 2785977..2789024 - 3048 WP_103245619.1 formate dehydrogenase-N subunit alpha -
C5523_RS13580 2789357..2790238 + 882 WP_079497452.1 aromatic amino acid DMT transporter YddG -
C5523_RS13585 2790304..2790750 + 447 WP_071194172.1 DUF2384 domain-containing protein Antitoxin
C5523_RS13590 2790750..2791226 + 477 WP_039079059.1 RES family NAD+ phosphorylase Toxin
C5523_RS13595 2791210..2792712 - 1503 WP_108701326.1 MFS transporter -
C5523_RS13600 2792825..2793415 + 591 WP_108701327.1 TetR family transcriptional regulator -
C5523_RS13605 2793397..2794239 - 843 WP_108701328.1 arylamine N-acetyltransferase -
C5523_RS13610 2794315..2795970 - 1656 WP_108701329.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-150)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(28-90)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 17725.30 Da        Isoelectric Point: 5.2290

>T97708 WP_039079059.1 NZ_CP027225:2790750-2791226 [Phytobacter sp. SCO41]
METVTFWRLVKERYALTAFDGYGARTFGGRWNSPGHECVYLGESKALCVLETLVHLEIEDIAQGYCFLTLDVPRNLIATL
DLTALPEDWKADPPPVSTQHIGDEWLASKQNGLVLRVPSTITGEWNALFNPEHPQAAKVLKSVKSEPFMLDPRLSRPC

Download         Length: 477 bp

>T97708 NZ_CP027225:2790750-2791226 [Phytobacter sp. SCO41]
ATGGAAACTGTCACCTTCTGGCGTCTGGTCAAAGAACGCTATGCGCTGACCGCCTTCGACGGTTACGGCGCGCGAACCTT
TGGCGGACGCTGGAATTCACCGGGGCATGAATGCGTCTACCTGGGTGAATCAAAAGCTCTCTGCGTGCTGGAAACACTGG
TACATCTTGAGATTGAAGATATCGCCCAGGGCTACTGTTTCTTAACGCTCGATGTACCGCGTAATCTTATCGCGACGCTG
GATTTGACCGCCCTGCCCGAAGACTGGAAAGCTGACCCGCCGCCTGTTTCCACGCAACACATCGGCGATGAGTGGCTGGC
ATCAAAGCAAAACGGGCTGGTACTGCGCGTCCCCAGTACCATCACCGGCGAATGGAACGCGCTGTTTAACCCCGAACACC
CACAGGCGGCGAAAGTCCTCAAAAGCGTAAAGTCCGAACCCTTTATGCTGGATCCCCGTCTTAGCCGTCCTTGCTAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 15690.07 Da        Isoelectric Point: 8.9810

>AT97708 WP_071194172.1 NZ_CP027225:2790304-2790750 [Phytobacter sp. SCO41]
MQLYTPGVRAIPHDLLSILGLPATAIAAHDSINAGLSAGVLRDIAGAVSLDEITLCRMAGIDRNTYSRRLNSAEKRFSPE
QSARVYTLARVISAARELFEGDSERMATWLNKPAKGLGGKKPAELLSTPAGAEAVLTLIGRLEHGVIG

Download         Length: 447 bp

>AT97708 NZ_CP027225:2790304-2790750 [Phytobacter sp. SCO41]
ATGCAACTCTATACACCGGGCGTACGCGCGATCCCGCACGACCTGCTCAGCATCCTGGGGCTGCCCGCCACGGCGATTGC
CGCTCATGACAGCATTAATGCCGGTCTGAGTGCAGGTGTGTTGCGTGATATCGCTGGCGCCGTCTCTCTTGATGAAATCA
CGCTGTGCCGAATGGCTGGCATTGATCGTAATACCTATAGCCGCAGGCTTAACAGCGCGGAAAAACGCTTTTCACCAGAA
CAGAGTGCGCGCGTCTACACGCTCGCACGAGTGATCAGCGCCGCTCGTGAGTTATTTGAAGGTGACAGCGAGCGTATGGC
CACCTGGCTCAATAAACCCGCGAAAGGCCTTGGCGGTAAAAAACCCGCAGAGCTTCTCTCGACCCCTGCCGGTGCGGAAG
CGGTACTGACATTGATTGGTCGCCTTGAGCACGGTGTGATCGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DED3

Antitoxin

Source ID Structure
AlphaFold DB A0A348DED2

References