Detailed information of TA system TA097707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 2737036..2737679
• Replicon: chromosome
• Accession: NZ_CP027225
• Organism: Phytobacter sp. SCO41

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: C5523_RS13325
• Protein ID: WP_108701297.1
• Coordinates: 2737263..2737679 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A348DE82
• Locus tag: C5523_RS13320
• Protein ID: WP_071194209.1
• Coordinates: 2737036..2737266 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5523_RS13300	2733199..2733576	+	378	WP_108701294.1	VOC family protein	-
C5523_RS13305	2733647..2734600	+	954	WP_108701295.1	2-hydroxyacid dehydrogenase	-
C5523_RS13310	2734652..2735416	+	765	WP_039079009.1	SDR family oxidoreductase	-
C5523_RS13315	2735492..2736778	-	1287	WP_108701296.1	MFS transporter	-
C5523_RS13320	2737036..2737266	+	231	WP_071194209.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
C5523_RS13325	2737263..2737679	+	417	WP_108701297.1	PIN domain-containing protein	Toxin
C5523_RS13330	2738596..2740692	+	2097	WP_108701298.1	50S ribosome-binding GTPase	-
C5523_RS13335	2740702..2742411	+	1710	WP_108701299.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-129)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14997.52 Da
• Isoelectric Point: 8.2990

>T97707 WP_108701297.1 NZ_CP027225:2737263-2737679 [Phytobacter sp. SCO41]
MKKTFMLDTNICSFIMREHPESVIKRLEQAVLCNNRIVVSAITYAEMRFGAIGKKASPHHAKLVDAFCARLDAVLAWDRA
AVDATTQIKLALALAGTPIGPNDTAIAGHAIAAGVVLVTNNTREFERVPGLILEDWAK

Nucleotide

• Length: 417 bp

>T97707 NZ_CP027225:2737263-2737679 [Phytobacter sp. SCO41]
ATGAAGAAAACCTTTATGCTCGACACTAATATTTGCTCATTCATTATGCGCGAGCATCCGGAAAGCGTTATTAAGCGTCT
GGAGCAGGCAGTGTTGTGCAACAATCGAATCGTAGTATCGGCTATCACCTATGCGGAAATGCGCTTCGGCGCGATCGGTA
AAAAGGCGTCGCCGCATCATGCGAAGCTGGTTGATGCGTTCTGTGCTCGCCTTGATGCCGTGCTAGCCTGGGACCGGGCG
GCAGTGGATGCCACTACGCAAATAAAGCTTGCGCTGGCGTTGGCTGGTACGCCGATTGGTCCGAACGATACCGCGATTGC
CGGGCATGCTATTGCCGCTGGCGTCGTGCTGGTAACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTGATTCTGG
AAGACTGGGCAAAATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8783.91 Da
• Isoelectric Point: 4.3654

>AT97707 WP_071194209.1 NZ_CP027225:2737036-2737266 [Phytobacter sp. SCO41]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIIREGDCIILRPVRPTWSSFAQLEKADPDFMAEREDVVSDEGRFDL

Nucleotide

• Length: 231 bp

>AT97707 NZ_CP027225:2737036-2737266 [Phytobacter sp. SCO41]
ATGCGAACCGTATCCATCTTCAAAAACGGCAACAATCGTGCCATCCGTCTGCCTCGCGATCTGGATTTCGAAGGAGTGAG
CGAACTGGAGATCATCAGGGAAGGGGACTGCATCATCCTGCGCCCGGTGCGACCGACGTGGAGTTCTTTCGCGCAATTAG
AAAAAGCCGACCCGGATTTTATGGCAGAACGTGAAGATGTGGTCAGTGATGAGGGACGCTTTGATCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A348DE82