Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1999145..1999616 Replicon chromosome
Accession NZ_CP027221
Organism Escherichia coli strain 2015C-3101

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag C6H98_RS10445 Protein ID WP_001303511.1
Coordinates 1999145..1999423 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag C6H98_RS10450 Protein ID WP_001302048.1
Coordinates 1999425..1999616 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H98_RS10405 1994452..1994721 - 270 WP_000003742.1 excisionase -
C6H98_RS10410 1994783..1997248 - 2466 WP_000048442.1 exonuclease -
C6H98_RS10415 1997341..1997532 - 192 WP_001090200.1 DUF1482 family protein -
C6H98_RS10420 1997529..1997717 - 189 WP_000449192.1 cell division inhibition protein DicB -
C6H98_RS10430 1998201..1998419 - 219 WP_001171930.1 hypothetical protein -
C6H98_RS10435 1998460..1998849 - 390 WP_001447517.1 hypothetical protein -
C6H98_RS10445 1999145..1999423 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C6H98_RS10450 1999425..1999616 - 192 WP_001302048.1 hypothetical protein Antitoxin
C6H98_RS10455 1999637..2000008 - 372 WP_001169687.1 hypothetical protein -
C6H98_RS10460 2000106..2000408 + 303 WP_001444689.1 transcriptional regulator -
C6H98_RS10465 2000405..2000830 + 426 WP_000693943.1 Rha family transcriptional regulator -
C6H98_RS10470 2000853..2001815 + 963 WP_000095671.1 helix-turn-helix domain-containing protein -
C6H98_RS10475 2001856..2002278 + 423 WP_001151120.1 DUF977 family protein -
C6H98_RS10480 2002275..2002529 + 255 WP_000004322.1 hypothetical protein -
C6H98_RS10485 2002522..2002833 + 312 WP_001002672.1 hypothetical protein -
C6H98_RS10490 2003139..2003717 + 579 WP_001204666.1 sce7726 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - espX7/nleL / espN / espN / espK 1986196..2050522 64326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T97679 WP_001303511.1 NZ_CP027221:c1999423-1999145 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T97679 NZ_CP027221:c1999423-1999145 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT97679 WP_001302048.1 NZ_CP027221:c1999616-1999425 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT97679 NZ_CP027221:c1999616-1999425 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References