Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4705550..4706385 Replicon chromosome
Accession NZ_CP027219
Organism Escherichia coli strain 2015C-3163

Toxin (Protein)


Gene name yeeV Uniprot ID F2VI91
Locus tag C6H73_RS25680 Protein ID WP_000854748.1
Coordinates 4706008..4706385 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H0IVG5
Locus tag C6H73_RS25675 Protein ID WP_001339471.1
Coordinates 4705550..4705918 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H73_RS25640 4702386..4702841 + 456 WP_000581504.1 hypothetical protein -
C6H73_RS25645 4702920..4703153 + 234 WP_001119729.1 DUF905 family protein -
C6H73_RS25655 4703253..4704071 + 819 WP_001234620.1 DUF945 domain-containing protein -
C6H73_RS25660 4704126..4704611 + 486 WP_000849570.1 antirestriction protein -
C6H73_RS25665 4704627..4705103 + 477 WP_001186727.1 RadC family protein -
C6H73_RS25670 4705166..4705387 + 222 WP_000692345.1 DUF987 domain-containing protein -
C6H73_RS25675 4705550..4705918 + 369 WP_001339471.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6H73_RS25680 4706008..4706385 + 378 WP_000854748.1 TA system toxin CbtA family protein Toxin
C6H73_RS25685 4706382..4706870 + 489 WP_000761721.1 hypothetical protein -
C6H73_RS25690 4706882..4707079 + 198 WP_000839281.1 DUF957 domain-containing protein -
C6H73_RS25695 4707176..4707748 + 573 WP_001290246.1 DUF4942 domain-containing protein -
C6H73_RS25705 4708497..4710035 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14179.16 Da        Isoelectric Point: 7.7761

>T97666 WP_000854748.1 NZ_CP027219:4706008-4706385 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T97666 NZ_CP027219:4706008-4706385 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13517.22 Da        Isoelectric Point: 6.4789

>AT97666 WP_001339471.1 NZ_CP027219:4705550-4705918 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT97666 NZ_CP027219:4705550-4705918 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2VI91

Antitoxin

Source ID Structure
AlphaFold DB A0A0H0IVG5

References