Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 541126..541958 Replicon chromosome
Accession NZ_CP027219
Organism Escherichia coli strain 2015C-3163

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag C6H73_RS02975 Protein ID WP_000854753.1
Coordinates 541126..541500 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9QGA8
Locus tag C6H73_RS02980 Protein ID WP_001280948.1
Coordinates 541590..541958 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6H73_RS02960 539766..540335 - 570 WP_001290252.1 DUF4942 domain-containing protein -
C6H73_RS02965 540432..540629 - 198 WP_000839281.1 DUF957 domain-containing protein -
C6H73_RS02970 540641..541129 - 489 WP_000777552.1 hypothetical protein -
C6H73_RS02975 541126..541500 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
C6H73_RS02980 541590..541958 - 369 WP_001280948.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C6H73_RS02985 542121..542342 - 222 WP_000692311.1 DUF987 domain-containing protein -
C6H73_RS02990 542405..542881 - 477 WP_001186726.1 RadC family protein -
C6H73_RS02995 542897..543382 - 486 WP_000849571.1 antirestriction protein -
C6H73_RS03000 543437..544255 - 819 WP_001234620.1 DUF945 domain-containing protein -
C6H73_RS03010 544355..544588 - 234 WP_001119729.1 DUF905 family protein -
C6H73_RS03015 544667..545038 - 372 WP_064758448.1 hypothetical protein -
C6H73_RS03020 545076..546289 + 1214 WP_162860179.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / espG / escE / cesAB / escK / escL / escR / escS / escT / escU / etgA / cesD / escC / sepD / escJ / escI / cesL / escV / escN / escO / sepQ/escQ / espH / cesF / map / tir / cesT / eae / escD / sepL / espA / espD / espB / cesD2 / escF / escG / espF / espK / efa1 / nleE / nleB1 / espL2 480620..610742 130122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T97644 WP_000854753.1 NZ_CP027219:c541500-541126 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T97644 NZ_CP027219:c541500-541126 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13609.50 Da        Isoelectric Point: 7.3991

>AT97644 WP_001280948.1 NZ_CP027219:c541958-541590 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT97644 NZ_CP027219:c541958-541590 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QGA8

References