Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 492107..492891 | Replicon | chromosome |
| Accession | NZ_CP027219 | ||
| Organism | Escherichia coli strain 2015C-3163 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A3E1VW18 |
| Locus tag | C6H73_RS02665 | Protein ID | WP_050869709.1 |
| Coordinates | 492107..492433 (-) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | C7BUQ9 |
| Locus tag | C6H73_RS02670 | Protein ID | WP_001285644.1 |
| Coordinates | 492523..492891 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C6H73_RS02635 | 487402..488379 | + | 978 | WP_000633206.1 | type II secretion system minor pseudopilin GspK | - |
| C6H73_RS02640 | 488376..489554 | + | 1179 | WP_000094966.1 | type II secretion system protein GspL | - |
| C6H73_RS02645 | 489556..490092 | + | 537 | WP_000942788.1 | GspM family type II secretion system protein YghD | - |
| C6H73_RS02650 | 490435..491277 | - | 843 | WP_001378387.1 | DUF4942 domain-containing protein | - |
| C6H73_RS02655 | 491362..491559 | - | 198 | WP_000839243.1 | DUF957 domain-containing protein | - |
| C6H73_RS02660 | 491571..492059 | - | 489 | WP_000761729.1 | hypothetical protein | - |
| C6H73_RS02665 | 492107..492433 | - | 327 | WP_050869709.1 | TA system toxin CbtA family protein | Toxin |
| C6H73_RS02670 | 492523..492891 | - | 369 | WP_001285644.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| C6H73_RS02675 | 493054..493275 | - | 222 | WP_000692319.1 | DUF987 domain-containing protein | - |
| C6H73_RS02680 | 493338..493814 | - | 477 | WP_001368782.1 | RadC family protein | - |
| C6H73_RS02685 | 493830..494303 | - | 474 | WP_001368734.1 | antirestriction protein | - |
| C6H73_RS02690 | 494397..494642 | - | 246 | WP_001164975.1 | hypothetical protein | - |
| C6H73_RS02695 | 494642..495193 | - | 552 | Protein_484 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / espG / escE / cesAB / escK / escL / escR / escS / escT / escU / etgA / cesD / escC / sepD / escJ / escI / cesL / escV / escN / escO / sepQ/escQ / espH / cesF / map / tir / cesT / eae / escD / sepL / espA / espD / espB / cesD2 / escF / escG / espF / espK / efa1 / nleE / nleB1 / espL2 | 480620..610742 | 130122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12208.98 Da Isoelectric Point: 6.8512
>T97643 WP_050869709.1 NZ_CP027219:c492433-492107 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLKDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN
MKTLPDTHVREASRCPSPVIIWQTLLTRLLDQHYGLTLKDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDN
Download Length: 327 bp
>T97643 NZ_CP027219:c492433-492107 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAAGGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTAA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAAGGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACTCGCGA
CAATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13533.31 Da Isoelectric Point: 5.0235
>AT97643 WP_001285644.1 NZ_CP027219:c492891-492523 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGVCLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT97643 NZ_CP027219:c492891-492523 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGTCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGTCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3E1VW18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | C7BUQ9 |