Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4268234..4268835 Replicon chromosome
Accession NZ_CP027218
Organism Pseudomonas sp. DTU12.3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag C2E19_RS19380 Protein ID WP_129394664.1
Coordinates 4268234..4268527 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag C2E19_RS19385 Protein ID WP_129394665.1
Coordinates 4268530..4268835 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E19_RS19355 4263544..4264233 + 690 WP_129394659.1 N-acetyltransferase -
C2E19_RS19360 4264238..4265422 + 1185 WP_129394660.1 GNAT family N-acetyltransferase -
C2E19_RS19365 4265394..4266185 + 792 WP_129394661.1 ChbG/HpnK family deacetylase -
C2E19_RS19370 4266300..4266992 + 693 WP_129394662.1 GNAT family N-acetyltransferase -
C2E19_RS19375 4267163..4267960 - 798 WP_129394663.1 class I SAM-dependent methyltransferase -
C2E19_RS19380 4268234..4268527 + 294 WP_129394664.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C2E19_RS19385 4268530..4268835 + 306 WP_129394665.1 putative addiction module antidote protein Antitoxin
C2E19_RS19390 4268943..4269290 + 348 WP_129394666.1 hypothetical protein -
C2E19_RS19395 4269434..4270864 - 1431 WP_129394667.1 sigma-54 dependent transcriptional regulator -
C2E19_RS19400 4270833..4272326 - 1494 WP_129394668.1 HAMP domain-containing histidine kinase -
C2E19_RS19405 4272421..4273500 - 1080 WP_129394669.1 SCO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(24-90)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10667.26 Da        Isoelectric Point: 11.2121

>T97640 WP_129394664.1 NZ_CP027218:4268234-4268527 [Pseudomonas sp. DTU12.3]
MNYLIRQTAVFQAWHQSVRDLRAKVAIARRIDRASTGNLGDVKSVGDGVSEMRVDVGAGFRVYFTMRNGAVIVLLAGGDK
SSQNADIRRAQKMAKEV

Download         Length: 294 bp

>T97640 NZ_CP027218:4268234-4268527 [Pseudomonas sp. DTU12.3]
ATGAATTATCTTATTCGACAAACAGCGGTATTTCAGGCTTGGCACCAATCGGTTCGAGACCTGCGGGCCAAGGTGGCCAT
CGCCCGCCGCATTGATCGGGCTTCAACAGGAAATCTCGGCGACGTCAAATCGGTGGGTGATGGCGTCTCTGAAATGCGCG
TAGATGTGGGTGCGGGCTTTCGGGTGTATTTCACGATGCGTAACGGTGCAGTCATCGTTCTTTTGGCTGGAGGCGACAAA
TCTTCACAAAACGCAGACATCCGACGCGCACAAAAAATGGCTAAGGAGGTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10990.55 Da        Isoelectric Point: 5.5656

>AT97640 WP_129394665.1 NZ_CP027218:4268530-4268835 [Pseudomonas sp. DTU12.3]
MSQTLTNFDMAALLDSDEAISEYLSQVLADGDNEEFLRAIGYVLKARGMTQIAKTSGMGRESLYKAFAPGAKPRFDTVLK
VMHALGIDLYAQPGHVSHPIS

Download         Length: 306 bp

>AT97640 NZ_CP027218:4268530-4268835 [Pseudomonas sp. DTU12.3]
ATGAGCCAGACGTTGACGAATTTCGACATGGCAGCACTGCTGGACAGTGACGAAGCCATCAGCGAATACCTGTCTCAGGT
ACTCGCAGACGGGGATAACGAAGAGTTTCTTCGCGCAATCGGCTATGTGCTCAAGGCGCGCGGGATGACGCAGATAGCCA
AAACTTCTGGCATGGGTCGCGAGAGTCTGTACAAGGCGTTCGCACCGGGTGCAAAACCGCGCTTCGACACGGTTTTGAAA
GTTATGCATGCCCTTGGCATCGATCTTTACGCACAGCCGGGGCACGTGAGCCACCCGATTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References