Detailed information of TA system TA097637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2078544..2079160
• Replicon: chromosome
• Accession: NZ_CP027218
• Organism: Pseudomonas sp. DTU12.3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: C2E19_RS09570
• Protein ID: WP_108226823.1
• Coordinates: 2078544..2078756 (+)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: C2E19_RS09575
• Protein ID: WP_129391002.1
• Coordinates: 2078756..2079160 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2E19_RS09540	2073713..2074183	+	471	WP_129390984.1	cytochrome c-type biogenesis protein CcmH	-
C2E19_RS09545	2074180..2075382	+	1203	WP_129390987.1	c-type cytochrome biogenesis protein CcmI	-
C2E19_RS09550	2075408..2075812	+	405	WP_129390991.1	hypothetical protein	-
C2E19_RS09555	2075911..2076792	-	882	WP_129390994.1	LysR family transcriptional regulator	-
C2E19_RS09560	2076922..2077641	-	720	WP_129390997.1	SDR family oxidoreductase	-
C2E19_RS09565	2077667..2078323	-	657	WP_129390999.1	AhpC/TSA family protein	-
C2E19_RS09570	2078544..2078756	+	213	WP_108226823.1	type II toxin-antitoxin system HicA family toxin	Toxin
C2E19_RS09575	2078756..2079160	+	405	WP_129391002.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C2E19_RS09580	2079336..2080523	-	1188	WP_129391005.1	MFS transporter	-
C2E19_RS09585	2080767..2081387	+	621	WP_129391008.1	hypothetical protein	-
C2E19_RS09590	2081504..2082502	-	999	WP_129391012.1	sulfate ABC transporter substrate-binding protein	-
C2E19_RS09600	2082684..2083508	-	825	WP_129391015.1	ion transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8017.15 Da
• Isoelectric Point: 10.1844

>T97637 WP_108226823.1 NZ_CP027218:2078544-2078756 [Pseudomonas sp. DTU12.3]
VQSRQLIKELEEAGWVLDRITGSHHIFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASYQGDP

Nucleotide

• Length: 213 bp

>T97637 NZ_CP027218:2078544-2078756 [Pseudomonas sp. DTU12.3]
GTGCAGAGCAGGCAATTGATCAAGGAGCTGGAGGAGGCTGGATGGGTGCTGGATCGGATCACTGGCAGTCATCACATCTT
CACTCACCGATACAACCCGTACACGATTCCCGTCCCTCACCCGAAAAAGGATTTGCCACTGGGGACGGTCAAAAGCATCA
GGAGGCGTGCCGGGCTGTACAACCCGCCAGCCAGTTACCAAGGAGATCCATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14812.83 Da
• Isoelectric Point: 4.3689

>AT97637 WP_129391002.1 NZ_CP027218:2078756-2079160 [Pseudomonas sp. DTU12.3]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYNAAVEIAHIMLQEIVASAEAIPMPTSAAAHRNNPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Nucleotide

• Length: 405 bp

>AT97637 NZ_CP027218:2078756-2079160 [Pseudomonas sp. DTU12.3]
ATGCAATATCCAATCTGCATTGAATGGGGCGACGAAAATACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACGGCAGGGGATAGCTTTGAAGATGCCTACAATGCGGCGGTTGAAATCGCCCACATCATGCTGCAAGAGATAGTGGCGA
GCGCAGAGGCGATCCCGATGCCCACTTCTGCAGCGGCGCATCGCAACAACCCGGAATTTGCCGACATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTATCTCGGCAAGACCGAGAAGGTCAACGTGACACTCCCCGGTTACGTGATCCAGCGAAT
CGATCGTTATGTGCGCGAACACAACGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGCT
ATTAA