Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2078544..2079160 Replicon chromosome
Accession NZ_CP027218
Organism Pseudomonas sp. DTU12.3

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C2E19_RS09570 Protein ID WP_108226823.1
Coordinates 2078544..2078756 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C2E19_RS09575 Protein ID WP_129391002.1
Coordinates 2078756..2079160 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2E19_RS09540 2073713..2074183 + 471 WP_129390984.1 cytochrome c-type biogenesis protein CcmH -
C2E19_RS09545 2074180..2075382 + 1203 WP_129390987.1 c-type cytochrome biogenesis protein CcmI -
C2E19_RS09550 2075408..2075812 + 405 WP_129390991.1 hypothetical protein -
C2E19_RS09555 2075911..2076792 - 882 WP_129390994.1 LysR family transcriptional regulator -
C2E19_RS09560 2076922..2077641 - 720 WP_129390997.1 SDR family oxidoreductase -
C2E19_RS09565 2077667..2078323 - 657 WP_129390999.1 AhpC/TSA family protein -
C2E19_RS09570 2078544..2078756 + 213 WP_108226823.1 type II toxin-antitoxin system HicA family toxin Toxin
C2E19_RS09575 2078756..2079160 + 405 WP_129391002.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C2E19_RS09580 2079336..2080523 - 1188 WP_129391005.1 MFS transporter -
C2E19_RS09585 2080767..2081387 + 621 WP_129391008.1 hypothetical protein -
C2E19_RS09590 2081504..2082502 - 999 WP_129391012.1 sulfate ABC transporter substrate-binding protein -
C2E19_RS09600 2082684..2083508 - 825 WP_129391015.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8017.15 Da        Isoelectric Point: 10.1844

>T97637 WP_108226823.1 NZ_CP027218:2078544-2078756 [Pseudomonas sp. DTU12.3]
VQSRQLIKELEEAGWVLDRITGSHHIFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYNPPASYQGDP

Download         Length: 213 bp

>T97637 NZ_CP027218:2078544-2078756 [Pseudomonas sp. DTU12.3]
GTGCAGAGCAGGCAATTGATCAAGGAGCTGGAGGAGGCTGGATGGGTGCTGGATCGGATCACTGGCAGTCATCACATCTT
CACTCACCGATACAACCCGTACACGATTCCCGTCCCTCACCCGAAAAAGGATTTGCCACTGGGGACGGTCAAAAGCATCA
GGAGGCGTGCCGGGCTGTACAACCCGCCAGCCAGTTACCAAGGAGATCCATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14812.83 Da        Isoelectric Point: 4.3689

>AT97637 WP_129391002.1 NZ_CP027218:2078756-2079160 [Pseudomonas sp. DTU12.3]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYNAAVEIAHIMLQEIVASAEAIPMPTSAAAHRNNPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT97637 NZ_CP027218:2078756-2079160 [Pseudomonas sp. DTU12.3]
ATGCAATATCCAATCTGCATTGAATGGGGCGACGAAAATACTGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACGGCAGGGGATAGCTTTGAAGATGCCTACAATGCGGCGGTTGAAATCGCCCACATCATGCTGCAAGAGATAGTGGCGA
GCGCAGAGGCGATCCCGATGCCCACTTCTGCAGCGGCGCATCGCAACAACCCGGAATTTGCCGACATGGGCTGGGGCATG
CTGGAGCTGGATATCTCGCCGTATCTCGGCAAGACCGAGAAGGTCAACGTGACACTCCCCGGTTACGTGATCCAGCGAAT
CGATCGTTATGTGCGCGAACACAACGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGCT
ATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References