Detailed information of TA system TA097636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-higA/HigB-HigA
• Location: 1116793..1117601
• Replicon: chromosome
• Accession: NZ_CP027218
• Organism: Pseudomonas sp. DTU12.3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: C2E19_RS04940
• Protein ID: WP_045123302.1
• Coordinates: 1116793..1117074 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C2E19_RS04945
• Protein ID: WP_008086988.1
• Coordinates: 1117128..1117601 (+)
• Length: 158 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2E19_RS04930	1113093..1115051	+	1959	WP_129388824.1	DUF1302 domain-containing protein	-
C2E19_RS04935	1115191..1116564	+	1374	WP_129388827.1	DUF1329 domain-containing protein	-
C2E19_RS04940	1116793..1117074	+	282	WP_045123302.1	type II toxin-antitoxin system HigB family toxin	Toxin
C2E19_RS04945	1117128..1117601	+	474	WP_008086988.1	transcriptional regulator	Antitoxin
C2E19_RS04950	1117748..1119667	-	1920	WP_129388830.1	methyl-accepting chemotaxis protein	-
C2E19_RS04955	1119921..1120592	+	672	WP_129388833.1	histidine phosphatase family protein	-
C2E19_RS04960	1120589..1121419	+	831	WP_129388836.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (49-87)

Antitoxin

• Antitoxin HigA (43-154)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11074.81 Da
• Isoelectric Point: 10.2188

>T97636 WP_045123302.1 NZ_CP027218:1116793-1117074 [Pseudomonas sp. DTU12.3]
MWLTIFDRASLRFESFEKLRQDWTSASGWNVDRIPHSKLRLTSKKGPLDIYVFDIKKNECRVITWINTKTGTIYIKDILP
HAGYDKWWKGDVK

Nucleotide

• Length: 282 bp

>T97636 NZ_CP027218:1116793-1117074 [Pseudomonas sp. DTU12.3]
TTGTGGCTAACCATCTTCGACAGAGCATCGCTGCGTTTCGAGTCATTTGAGAAGCTTCGTCAAGACTGGACCAGCGCCTC
AGGTTGGAACGTCGATCGTATCCCTCACTCGAAGCTGAGGCTGACGAGCAAGAAAGGCCCGCTTGATATTTACGTTTTTG
ATATCAAGAAAAACGAGTGCCGTGTCATTACGTGGATCAATACGAAGACTGGCACTATCTATATCAAGGACATTCTTCCC
CATGCCGGATATGACAAATGGTGGAAGGGTGATGTCAAGTAG

Antitoxin

Protein

• Length: 158 a.a.
• Molecular weight: 17491.88 Da
• Isoelectric Point: 4.6243

>AT97636 WP_008086988.1 NZ_CP027218:1117128-1117601 [Pseudomonas sp. DTU12.3]
MKRNKVEATGLDSFIADISPMLEGLGDQLATLSKLLSACHDPIKNDDDLQVRMALIDELYSHANTEDHAAARFAEFVADR
VYEYESETVLIAYSSQSEALAFLLSERGVKQKDLSEIATQSAVSEILNNKRKMTVAQIKGFAEFFKVPVEFFMHGVV

Nucleotide

• Length: 474 bp

>AT97636 NZ_CP027218:1117128-1117601 [Pseudomonas sp. DTU12.3]
ATGAAGCGTAATAAAGTCGAAGCGACAGGACTGGATTCCTTCATAGCCGATATTTCACCCATGCTTGAGGGACTGGGCGA
TCAGCTAGCGACTTTGTCCAAGTTGTTGTCTGCCTGCCATGATCCGATAAAAAATGATGACGATCTGCAAGTGCGAATGG
CCCTGATTGATGAGCTTTATTCCCACGCAAACACCGAGGATCATGCTGCTGCACGGTTTGCGGAGTTTGTGGCTGATCGG
GTTTATGAGTACGAGAGTGAAACGGTGTTGATTGCTTATTCGTCCCAATCTGAAGCGCTGGCGTTTCTGCTGTCGGAAAG
AGGCGTCAAACAGAAGGACTTGTCTGAGATCGCAACTCAGAGTGCTGTTTCAGAGATATTGAATAACAAACGAAAAATGA
CCGTTGCCCAGATAAAGGGATTCGCCGAGTTCTTTAAAGTGCCGGTCGAGTTTTTTATGCACGGTGTGGTTTGA