Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2849573..2850417 Replicon chromosome
Accession NZ_CP027205
Organism Escherichia coli strain WCHEC025943

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CXB56_RS17530 Protein ID WP_000854686.1
Coordinates 2849573..2849956 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag CXB56_RS17535 Protein ID WP_001285602.1
Coordinates 2850037..2850417 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXB56_RS17490 2844576..2845067 - 492 WP_001297187.1 DUF1097 domain-containing protein -
CXB56_RS17495 2845169..2845723 - 555 WP_001001902.1 molecular chaperone YcdY -
CXB56_RS17500 2845747..2846484 - 738 WP_000283664.1 zinc-binding phosphatase -
CXB56_RS17505 2846539..2847477 - 939 WP_000351311.1 glyoxylate/hydroxypyruvate reductase GhrA -
CXB56_RS17515 2847948..2848789 - 842 Protein_2731 DUF4942 domain-containing protein -
CXB56_RS17520 2848874..2849071 - 198 WP_000839253.1 DUF957 domain-containing protein -
CXB56_RS17525 2849088..2849576 - 489 WP_032180032.1 hypothetical protein -
CXB56_RS17530 2849573..2849956 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CXB56_RS17535 2850037..2850417 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CXB56_RS17540 2850428..2851111 - 684 WP_000086768.1 hypothetical protein -
CXB56_RS17545 2851130..2851351 - 222 WP_000692298.1 DUF987 domain-containing protein -
CXB56_RS17550 2851414..2851890 - 477 WP_001186726.1 RadC family protein -
CXB56_RS17555 2851906..2852391 - 486 WP_000214307.1 antirestriction protein -
CXB56_RS17560 2852483..2853304 - 822 WP_001761104.1 DUF945 domain-containing protein -
CXB56_RS17570 2853405..2853613 - 209 Protein_2741 DUF905 domain-containing protein -
CXB56_RS17575 2853714..2854169 - 456 WP_000581506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCMY-2 csgB / csgD / csgE / csgF / csgG 2840958..2896924 55966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T97630 WP_000854686.1 NZ_CP027205:c2849956-2849573 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T97630 NZ_CP027205:c2849956-2849573 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT97630 WP_001285602.1 NZ_CP027205:c2850417-2850037 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT97630 NZ_CP027205:c2850417-2850037 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References