Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1682651..1683308 Replicon chromosome
Accession NZ_CP027189
Organism Klebsiella pneumoniae strain KPHS1249

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag C5Z24_RS08515 Protein ID WP_002916310.1
Coordinates 1682898..1683308 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag C5Z24_RS08510 Protein ID WP_002916312.1
Coordinates 1682651..1682917 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Z24_RS08485 1677859..1679292 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
C5Z24_RS08490 1679411..1680139 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
C5Z24_RS08495 1680189..1680500 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
C5Z24_RS08500 1680664..1681323 + 660 WP_002916317.1 hemolysin III family protein -
C5Z24_RS08505 1681422..1682405 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
C5Z24_RS08510 1682651..1682917 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
C5Z24_RS08515 1682898..1683308 + 411 WP_002916310.1 protein YgfX Toxin
C5Z24_RS08520 1683315..1683836 - 522 WP_002916308.1 flavodoxin FldB -
C5Z24_RS08525 1683937..1684833 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
C5Z24_RS08530 1684856..1685569 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
C5Z24_RS08535 1685575..1687308 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T97597 WP_002916310.1 NZ_CP027189:1682898-1683308 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T97597 NZ_CP027189:1682898-1683308 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT97597 WP_002916312.1 NZ_CP027189:1682651-1682917 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT97597 NZ_CP027189:1682651-1682917 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References