Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 25725..26250 Replicon plasmid unnamed1
Accession NZ_CP027179
Organism Acinetobacter baumannii strain AR_0070

Toxin (Protein)


Gene name relE Uniprot ID A0A7U3Y3F8
Locus tag CSB70_RS20250 Protein ID WP_000221350.1
Coordinates 25963..26250 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R9B9T8
Locus tag CSB70_RS20245 Protein ID WP_000192612.1
Coordinates 25725..25973 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB70_RS20210 22064..22258 - 195 Protein_23 hypothetical protein -
CSB70_RS20215 22253..22591 + 339 Protein_24 DUF3387 domain-containing protein -
CSB70_RS20220 22796..23743 - 948 WP_000845976.1 replication initiation protein RepM -
CSB70_RS20225 24168..24797 + 630 WP_000584713.1 AAA family ATPase -
CSB70_RS20230 24794..25030 + 237 WP_000592589.1 hypothetical protein -
CSB70_RS20235 25146..25214 + 69 Protein_28 helix-turn-helix domain-containing protein -
CSB70_RS20240 25297..25722 + 426 WP_001083446.1 hypothetical protein -
CSB70_RS20245 25725..25973 + 249 WP_000192612.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB70_RS20250 25963..26250 + 288 WP_000221350.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSB70_RS20255 26522..27772 + 1251 Protein_32 IS3 family transposase -
CSB70_RS20260 28409..28975 + 567 WP_000678311.1 recombinase family protein -
CSB70_RS20265 29177..29491 - 315 WP_000723215.1 hypothetical protein -
CSB70_RS20270 29494..29907 - 414 WP_005020944.1 hypothetical protein -
CSB70_RS20275 30091..30393 - 303 Protein_36 IS1-like element ISAba3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-58 - 1..39535 39535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11054.85 Da        Isoelectric Point: 10.0443

>T97567 WP_000221350.1 NZ_CP027179:25963-26250 [Acinetobacter baumannii]
MTYKLDFLEEALAEWNKLNPSIKQPLKKKLIKVLENPHIPKNKLSGHPNRYKIKLRSVGYRLVYEVIDDEVVVIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T97567 NZ_CP027179:25963-26250 [Acinetobacter baumannii]
ATGACCTATAAGTTAGACTTTTTAGAAGAAGCATTAGCAGAATGGAATAAGCTTAATCCAAGTATTAAGCAACCATTGAA
GAAGAAACTGATCAAGGTACTAGAGAATCCTCACATTCCCAAGAATAAGCTCTCAGGACATCCTAACCGCTACAAGATCA
AACTTCGCAGTGTTGGTTATCGTTTGGTTTATGAAGTGATTGATGATGAGGTTGTTGTCATCGTCATTGCCGTAGGCAGA
CGTGAAAACAATGCTGTGTATGATGAAGCCAACTCTCGACATTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9246.72 Da        Isoelectric Point: 5.0491

>AT97567 WP_000192612.1 NZ_CP027179:25725-25973 [Acinetobacter baumannii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNTPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT97567 NZ_CP027179:25725-25973 [Acinetobacter baumannii]
ATGACTCAATTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCGATGGATACAGTGTTAGCAGG
TAAAGGTGAACCTGTAGCGATCCTTAATCGTAATACACCAGCGTTTTACTGTGTTCCGGCTGATTTGTATGAAACCATGA
TGGAACAACTGGAAGACCTGGAACTCAACAAAATTGCAGATGCTCGTGCGAATCAAAAACGCATTCGAGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3Y3F8

Antitoxin

Source ID Structure
AlphaFold DB R9B9T8

References