Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3301424..3302077 Replicon chromosome
Accession NZ_CP027178
Organism Acinetobacter baumannii strain AR_0070

Toxin (Protein)


Gene name cptA Uniprot ID A0A246A3V9
Locus tag CSB70_RS16220 Protein ID WP_002054941.1
Coordinates 3301424..3301813 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag CSB70_RS16225 Protein ID WP_001288210.1
Coordinates 3301820..3302077 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB70_RS16205 3296546..3298737 - 2192 Protein_3122 TRAP transporter large permease subunit -
CSB70_RS16210 3298925..3299491 - 567 WP_000651536.1 rhombosortase -
CSB70_RS16215 3299569..3300654 - 1086 WP_000049106.1 hypothetical protein -
CSB70_RS16220 3301424..3301813 - 390 WP_002054941.1 hypothetical protein Toxin
CSB70_RS16225 3301820..3302077 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
CSB70_RS16230 3302265..3303437 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
CSB70_RS16235 3303487..3304977 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
CSB70_RS16240 3305159..3305536 - 378 WP_001216380.1 50S ribosomal protein L17 -
CSB70_RS16245 3305555..3306562 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15616.87 Da        Isoelectric Point: 10.2790

>T97566 WP_002054941.1 NZ_CP027178:c3301813-3301424 [Acinetobacter baumannii]
MINHLNFKLKYSHFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T97566 NZ_CP027178:c3301813-3301424 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCATTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT97566 WP_001288210.1 NZ_CP027178:c3302077-3301820 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT97566 NZ_CP027178:c3302077-3301820 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246A3V9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References