Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1193019..1193836 Replicon chromosome
Accession NZ_CP027177
Organism Morganella morganii strain AR_0057

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A2C5TM43
Locus tag CSB69_RS05455 Protein ID WP_004236532.1
Coordinates 1193354..1193836 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag CSB69_RS05450 Protein ID WP_004236533.1
Coordinates 1193019..1193327 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB69_RS05425 1188326..1188532 - 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -
CSB69_RS05430 1188600..1189631 - 1032 WP_105369869.1 inner membrane protein YhjD -
CSB69_RS05435 1190043..1190432 - 390 WP_004236536.1 DUF1090 domain-containing protein -
CSB69_RS05440 1190622..1191464 + 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
CSB69_RS05445 1191534..1192886 + 1353 WP_004240744.1 glutathione-disulfide reductase -
CSB69_RS05450 1193019..1193327 + 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
CSB69_RS05455 1193354..1193836 + 483 WP_004236532.1 GNAT family N-acetyltransferase Toxin
CSB69_RS20365 1193950..1194090 - 141 WP_004236531.1 hypothetical protein -
CSB69_RS05460 1194087..1194608 - 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
CSB69_RS05465 1194736..1195038 - 303 WP_004240743.1 exported protein precursor -
CSB69_RS05470 1195253..1196368 - 1116 WP_004240742.1 molybdenum cofactor guanylyltransferase MobA -
CSB69_RS05475 1196571..1196840 + 270 WP_004240741.1 YihD family protein -
CSB69_RS05480 1196840..1197835 + 996 WP_004240740.1 serine/threonine protein kinase -
CSB69_RS05485 1197854..1198477 + 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(36-135)

Antitoxin

Vibrio phage ICP1, Orf50

(21-94)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17729.48 Da        Isoelectric Point: 10.2370

>T97563 WP_004236532.1 NZ_CP027177:1193354-1193836 [Morganella morganii]
MQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGR
LAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Download         Length: 483 bp

>T97563 NZ_CP027177:1193354-1193836 [Morganella morganii]
TTGCAGCAGCATCATGATTTTACCGTTTTTCAGTCAGGTGAGGAGTCCCTTAACCATTGGCTGAAAACCCGCGCATTGCA
AAATCAGCAATCCGGAGCCTCACGGACATTTGTCGTCTGCCACCATAACCGGATAATGGCCTATTATGCATTATCGACAG
GTGTGATTACCTGTTCACAGGCGGCGGGTCGTTTCAGGCGTAATATGCCCCCGGAAATTCCGGTTATCCTGCCGGGACGT
CTTGCTGTTGACGAAAGCGTAAAAGGCAGAGGGATCGGACGGGGTCTGATAAAAGATGCCGCACTGCGGGTCTTGCAGGC
GGCCGGGATTGTGGGTATCCGCGGTATTGTTGTCCGTGCTCTGTCTGATAATGCCAGACGTTTTTATGAGCATACCGGTT
TTATGCCGTCACCGGCTGACCCGATGCTGCTGATGATTACATTACGGGATCTGCAGCTGGCAACCGGTATCTATTCTGAA
TAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT97563 WP_004236533.1 NZ_CP027177:1193019-1193327 [Morganella morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT97563 NZ_CP027177:1193019-1193327 [Morganella morganii]
ATGACAAAACACACAGATGAGCAGCATCCTGTGTCCGGCGTGAATATCACCCGTTCAACACTGAATTTACGCATCAAACC
GGAAGATAAAATTCTGATTGATCGCGCAGCGCATGCTGCCGGTAAAAACAGAACCGAGTTCGTACTGGAAGCTGCGCGGC
GTGCCGCCGAAGAAACACTGGCAGATTTACGGGTTATTGATGTCAGTACCGATGTCTATCAGCAGTTTATTACCAGACTG
GATATGGCACCACAGTCCGGTGAGGCGCTGAAGAAGACCATGCTGACGAAGGCGCCGTGGGAGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C5TM43

Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References