Detailed information of TA system TA097560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 5696082..5696587
• Replicon: chromosome
• Accession: NZ_CP027174
• Organism: Pseudomonas aeruginosa strain AR_0230

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: CSB85_RS27120
• Protein ID: WP_003083773.1
• Coordinates: 5696082..5696363 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CSB85_RS27125
• Protein ID: WP_003083775.1
• Coordinates: 5696360..5696587 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB85_RS27095	5691333..5692682	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
CSB85_RS27100	5692731..5693417	+	687	WP_003083762.1	FadR family transcriptional regulator	-
CSB85_RS27105	5693518..5694252	+	735	WP_003117208.1	GntR family transcriptional regulator	-
CSB85_RS27110	5694456..5694842	+	387	WP_003083767.1	aegerolysin family protein	-
CSB85_RS27115	5694874..5695782	-	909	WP_003083769.1	LysR family transcriptional regulator	-
CSB85_RS27120	5696082..5696363	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
CSB85_RS27125	5696360..5696587	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CSB85_RS27130	5696762..5697382	-	621	WP_003101226.1	hypothetical protein	-
CSB85_RS27135	5697483..5697983	+	501	WP_003162763.1	LEA type 2 family protein	-
CSB85_RS27140	5698056..5698397	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
CSB85_RS27145	5698479..5699906	-	1428	WP_003083784.1	GABA permease	-
CSB85_RS27150	5700075..5701568	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T97560 WP_003083773.1 NZ_CP027174:c5696363-5696082 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T97560 NZ_CP027174:c5696363-5696082 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT97560 WP_003083775.1 NZ_CP027174:c5696587-5696360 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT97560 NZ_CP027174:c5696587-5696360 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9