Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 7199683..7200188 Replicon chromosome
Accession NZ_CP027172
Organism Pseudomonas aeruginosa strain AR_0353

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CSB90_RS35010 Protein ID WP_003083773.1
Coordinates 7199907..7200188 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CSB90_RS35005 Protein ID WP_003083775.1
Coordinates 7199683..7199910 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB90_RS34980 7194701..7196194 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CSB90_RS34985 7196363..7197790 + 1428 WP_003083784.1 GABA permease -
CSB90_RS34990 7197872..7198213 - 342 WP_003101229.1 alkylphosphonate utilization protein -
CSB90_RS34995 7198286..7198786 - 501 WP_003128336.1 LEA type 2 family protein -
CSB90_RS35000 7198887..7199507 + 621 WP_003101226.1 hypothetical protein -
CSB90_RS35005 7199683..7199910 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CSB90_RS35010 7199907..7200188 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CSB90_RS35015 7200488..7201396 + 909 WP_003083769.1 LysR family transcriptional regulator -
CSB90_RS35020 7201428..7201814 - 387 WP_003083767.1 aegerolysin family protein -
CSB90_RS35025 7202018..7202752 - 735 WP_003128333.1 GntR family transcriptional regulator -
CSB90_RS35030 7202853..7203539 - 687 WP_003083762.1 FadR family transcriptional regulator -
CSB90_RS35035 7203588..7204937 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T97551 WP_003083773.1 NZ_CP027172:7199907-7200188 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T97551 NZ_CP027172:7199907-7200188 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT97551 WP_003083775.1 NZ_CP027172:7199683-7199910 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT97551 NZ_CP027172:7199683-7199910 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References