97541

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4809676..4810181 Replicon chromosome
Accession NZ_CP027171
Organism Pseudomonas aeruginosa strain AR_0354

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CSB91_RS22675 Protein ID WP_003083773.1
Coordinates 4809676..4809957 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag CSB91_RS22680 Protein ID WP_003083775.1
Coordinates 4809954..4810181 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB91_RS22650 4804927..4806276 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
CSB91_RS22655 4806325..4807011 + 687 WP_003083762.1 FadR family transcriptional regulator -
CSB91_RS22660 4807112..4807846 + 735 WP_003083764.1 GntR family transcriptional regulator -
CSB91_RS22665 4808050..4808436 + 387 WP_003083767.1 aegerolysin family protein -
CSB91_RS22670 4808468..4809376 - 909 WP_003083769.1 LysR family transcriptional regulator -
CSB91_RS22675 4809676..4809957 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CSB91_RS22680 4809954..4810181 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
CSB91_RS22685 4810357..4810977 - 621 WP_003101226.1 hypothetical protein -
CSB91_RS22690 4811078..4811578 + 501 WP_003083778.1 LEA type 2 family protein -
CSB91_RS22695 4811651..4811992 + 342 WP_014603467.1 alkylphosphonate utilization protein -
CSB91_RS22700 4812074..4813501 - 1428 WP_003083784.1 GABA permease -
CSB91_RS22705 4813670..4815163 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T97541 WP_003083773.1 NZ_CP027171:c4809957-4809676 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T97541 NZ_CP027171:c4809957-4809676 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT97541 WP_003083775.1 NZ_CP027171:c4810181-4809954 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT97541 NZ_CP027171:c4810181-4809954 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References