Detailed information of TA system TA097531

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1522022..1522527
• Replicon: chromosome
• Accession: NZ_CP027166
• Organism: Pseudomonas aeruginosa strain AR_0357

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: CSB94_RS07515
• Protein ID: WP_003083773.1
• Coordinates: 1522246..1522527 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CSB94_RS07510
• Protein ID: WP_003083775.1
• Coordinates: 1522022..1522249 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB94_RS07485	1517040..1518533	+	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-
CSB94_RS07490	1518702..1520129	+	1428	WP_003083784.1	GABA permease	-
CSB94_RS07495	1520211..1520552	-	342	WP_014603467.1	alkylphosphonate utilization protein	-
CSB94_RS07500	1520625..1521125	-	501	WP_003083778.1	LEA type 2 family protein	-
CSB94_RS07505	1521226..1521846	+	621	WP_003101226.1	hypothetical protein	-
CSB94_RS07510	1522022..1522249	+	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CSB94_RS07515	1522246..1522527	+	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
CSB94_RS07520	1522827..1523735	+	909	WP_003083769.1	LysR family transcriptional regulator	-
CSB94_RS07525	1523767..1524153	-	387	WP_003083767.1	aegerolysin family protein	-
CSB94_RS07530	1524357..1525091	-	735	WP_003083764.1	GntR family transcriptional regulator	-
CSB94_RS07535	1525192..1525878	-	687	WP_003083762.1	FadR family transcriptional regulator	-
CSB94_RS07540	1525927..1527276	-	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T97531 WP_003083773.1 NZ_CP027166:1522246-1522527 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T97531 NZ_CP027166:1522246-1522527 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT97531 WP_003083775.1 NZ_CP027166:1522022-1522249 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT97531 NZ_CP027166:1522022-1522249 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGATGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9