Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 327568..328187 Replicon chromosome
Accession NZ_CP027160
Organism Klebsiella pneumoniae strain AR_0361

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CSB98_RS02585 Protein ID WP_002892050.1
Coordinates 327568..327786 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag CSB98_RS02590 Protein ID WP_002892066.1
Coordinates 327813..328187 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB98_RS02555 323615..323878 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
CSB98_RS02560 323878..324018 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
CSB98_RS02565 324015..324713 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
CSB98_RS02570 324814..326265 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
CSB98_RS02575 326240..326710 - 471 WP_002892026.1 YlaC family protein -
CSB98_RS28870 326731..326871 + 141 WP_004147370.1 hypothetical protein -
CSB98_RS02580 326843..327409 - 567 WP_002892030.1 maltose O-acetyltransferase -
CSB98_RS02585 327568..327786 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CSB98_RS02590 327813..328187 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
CSB98_RS02595 328673..331819 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
CSB98_RS02600 331842..333035 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T97505 WP_002892050.1 NZ_CP027160:c327786-327568 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T97505 NZ_CP027160:c327786-327568 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT97505 WP_002892066.1 NZ_CP027160:c328187-327813 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT97505 NZ_CP027160:c328187-327813 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References