97481

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 194835..195361 Replicon plasmid unnamed1
Accession NZ_CP027144
Organism Enterobacter hormaechei subsp. hoffmannii strain AR_0365

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CSC02_RS25355 Protein ID WP_000323025.1
Coordinates 194835..195122 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CSC02_RS25360 Protein ID WP_000534858.1
Coordinates 195122..195361 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC02_RS27145 190405..190581 - 177 WP_001371930.1 hypothetical protein -
CSC02_RS25325 191092..192036 + 945 WP_000778029.1 DUF5417 domain-containing protein -
CSC02_RS25330 192132..192734 + 603 WP_012695474.1 hypothetical protein -
CSC02_RS25335 192794..193144 + 351 WP_000743059.1 hypothetical protein -
CSC02_RS25340 193191..193394 + 204 WP_001015183.1 hypothetical protein -
CSC02_RS25345 193676..193996 + 321 WP_000332796.1 hypothetical protein -
CSC02_RS25350 194605..194763 - 159 WP_001447866.1 type I toxin-antitoxin system Hok family toxin -
CSC02_RS25355 194835..195122 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CSC02_RS25360 195122..195361 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CSC02_RS25370 195624..196547 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
CSC02_RS25375 196747..197319 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
CSC02_RS25380 197795..199033 - 1239 WP_000219087.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / sul1 / qacE / ere(A) / aac(6')-IIc / aadA2 / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 - 1..328871 328871


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T97481 WP_000323025.1 NZ_CP027144:c195122-194835 [Enterobacter hormaechei subsp. hoffmannii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T97481 NZ_CP027144:c195122-194835 [Enterobacter hormaechei subsp. hoffmannii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT97481 WP_000534858.1 NZ_CP027144:c195361-195122 [Enterobacter hormaechei subsp. hoffmannii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT97481 NZ_CP027144:c195361-195122 [Enterobacter hormaechei subsp. hoffmannii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References