Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3151704..3152383 | Replicon | chromosome |
| Accession | NZ_CP027142 | ||
| Organism | Enterobacter hormaechei subsp. hoffmannii strain AR_0365 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | A0A7Y6TU48 |
| Locus tag | CSC02_RS15650 | Protein ID | WP_063146966.1 |
| Coordinates | 3151704..3152045 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | A0A7Y6NHZ8 |
| Locus tag | CSC02_RS15655 | Protein ID | WP_063146965.1 |
| Coordinates | 3152066..3152383 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CSC02_RS15605 | 3146887..3147036 | - | 150 | WP_017382390.1 | DUF3927 family protein | - |
| CSC02_RS15610 | 3147036..3147461 | - | 426 | WP_023307010.1 | tellurite resistance TerB family protein | - |
| CSC02_RS15615 | 3147531..3147731 | - | 201 | WP_017382392.1 | hypothetical protein | - |
| CSC02_RS15620 | 3147721..3147945 | - | 225 | WP_023307011.1 | DUF2724 domain-containing protein | - |
| CSC02_RS15625 | 3147953..3148462 | - | 510 | WP_105322855.1 | phage regulatory CII family protein | - |
| CSC02_RS15630 | 3148497..3148733 | - | 237 | WP_015386350.1 | hypothetical protein | - |
| CSC02_RS15635 | 3148835..3149449 | + | 615 | WP_032610574.1 | phage repressor protein CI | - |
| CSC02_RS15640 | 3149461..3150360 | + | 900 | WP_032610575.1 | NAD-dependent DNA ligase | - |
| CSC02_RS15645 | 3150370..3151383 | + | 1014 | WP_032610576.1 | tyrosine-type recombinase/integrase | - |
| CSC02_RS15650 | 3151704..3152045 | - | 342 | WP_063146966.1 | toxin | Toxin |
| CSC02_RS15655 | 3152066..3152383 | - | 318 | WP_063146965.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CSC02_RS15660 | 3152401..3152622 | - | 222 | WP_063146964.1 | DUF987 domain-containing protein | - |
| CSC02_RS15665 | 3152631..3153107 | - | 477 | WP_063146963.1 | RadC family protein | - |
| CSC02_RS15670 | 3153123..3153602 | - | 480 | WP_015063037.1 | antirestriction protein | - |
| CSC02_RS15675 | 3154456..3156651 | - | 2196 | WP_063146962.1 | DEAD/DEAH box helicase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3116834..3166272 | 49438 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12924.07 Da Isoelectric Point: 9.1353
>T97477 WP_063146966.1 NZ_CP027142:c3152045-3151704 [Enterobacter hormaechei subsp. hoffmannii]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRMGF
SWQEQSPYIRAVDILRARQATGLLQQSRKNLVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRMGF
SWQEQSPYIRAVDILRARQATGLLQQSRKNLVR
Download Length: 342 bp
>T97477 NZ_CP027142:c3152045-3151704 [Enterobacter hormaechei subsp. hoffmannii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTGGCCGATGCCGTTAATTTTCTGGTGGAGAAATACGAGCTGGTGCGTATCGACAGAATGGGATTT
AGCTGGCAGGAGCAATCTCCTTATATTCGGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGTCTGTTACAGCAAAG
CCGTAAAAATTTGGTACGGTGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTGGCCGATGCCGTTAATTTTCTGGTGGAGAAATACGAGCTGGTGCGTATCGACAGAATGGGATTT
AGCTGGCAGGAGCAATCTCCTTATATTCGGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGTCTGTTACAGCAAAG
CCGTAAAAATTTGGTACGGTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12034.71 Da Isoelectric Point: 7.0269
>AT97477 WP_063146965.1 NZ_CP027142:c3152383-3152066 [Enterobacter hormaechei subsp. hoffmannii]
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIECRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSKITWGLQRDITPRLGARLVQEGNRLHYLADRASMTGKFSDIECRKLDETFPHFIRQMESMLTTGELSTHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT97477 NZ_CP027142:c3152383-3152066 [Enterobacter hormaechei subsp. hoffmannii]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y6TU48 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y6NHZ8 |