Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2893522..2894179 Replicon chromosome
Accession NZ_CP027142
Organism Enterobacter hormaechei subsp. hoffmannii strain AR_0365

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag CSC02_RS14290 Protein ID WP_022649305.1
Coordinates 2893522..2893932 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag CSC02_RS14295 Protein ID WP_003863437.1
Coordinates 2893913..2894179 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC02_RS14270 2889520..2891253 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
CSC02_RS14275 2891259..2891972 - 714 WP_023306885.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSC02_RS14280 2892001..2892897 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
CSC02_RS14285 2892999..2893520 + 522 WP_023306886.1 flavodoxin FldB -
CSC02_RS14290 2893522..2893932 - 411 WP_022649305.1 protein YgfX Toxin
CSC02_RS14295 2893913..2894179 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
CSC02_RS14300 2894474..2895454 + 981 WP_023298542.1 tRNA-modifying protein YgfZ -
CSC02_RS14310 2895978..2896637 - 660 WP_022649307.1 hemolysin III family protein -
CSC02_RS14315 2896904..2897635 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T97476 WP_022649305.1 NZ_CP027142:c2893932-2893522 [Enterobacter hormaechei subsp. hoffmannii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T97476 NZ_CP027142:c2893932-2893522 [Enterobacter hormaechei subsp. hoffmannii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAGATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT97476 WP_003863437.1 NZ_CP027142:c2894179-2893913 [Enterobacter hormaechei subsp. hoffmannii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT97476 NZ_CP027142:c2894179-2893913 [Enterobacter hormaechei subsp. hoffmannii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References