Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 203041..203662 Replicon chromosome
Accession NZ_CP027142
Organism Enterobacter hormaechei subsp. hoffmannii strain AR_0365

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag CSC02_RS01180 Protein ID WP_015571250.1
Coordinates 203041..203259 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag CSC02_RS01185 Protein ID WP_006809850.1
Coordinates 203288..203662 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC02_RS01150 199053..199313 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
CSC02_RS01155 199316..199456 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CSC02_RS01160 199453..200163 - 711 WP_105322505.1 GNAT family N-acetyltransferase -
CSC02_RS01165 200266..201726 + 1461 WP_105322506.1 PLP-dependent aminotransferase family protein -
CSC02_RS01170 201698..202165 - 468 WP_022647269.1 hypothetical protein -
CSC02_RS01175 202282..202833 - 552 WP_022647270.1 maltose O-acetyltransferase -
CSC02_RS01180 203041..203259 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
CSC02_RS01185 203288..203662 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
CSC02_RS01190 204172..207318 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit -
CSC02_RS01195 207341..208534 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T97466 WP_015571250.1 NZ_CP027142:c203259-203041 [Enterobacter hormaechei subsp. hoffmannii]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T97466 NZ_CP027142:c203259-203041 [Enterobacter hormaechei subsp. hoffmannii]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAGCGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT97466 WP_006809850.1 NZ_CP027142:c203662-203288 [Enterobacter hormaechei subsp. hoffmannii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT97466 NZ_CP027142:c203662-203288 [Enterobacter hormaechei subsp. hoffmannii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References