Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4328911..4329437 Replicon chromosome
Accession NZ_CP027140
Organism Escherichia coli strain AR_0369

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CSC06_RS24485 Protein ID WP_000323025.1
Coordinates 4329150..4329437 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CSC06_RS24480 Protein ID WP_000534858.1
Coordinates 4328911..4329150 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC06_RS24440 4324097..4324324 + 228 WP_000476993.1 transcriptional regulator -
CSC06_RS24445 4324308..4324829 + 522 WP_000705349.1 hypothetical protein -
CSC06_RS24450 4324810..4325775 + 966 WP_000054504.1 hypothetical protein -
CSC06_RS24455 4325816..4326235 + 420 WP_001151196.1 DUF977 family protein -
CSC06_RS24460 4326269..4327609 + 1341 WP_000589012.1 ISNCY family transposase -
CSC06_RS24470 4328046..4328378 - 333 WP_001317460.1 FlxA-like family protein -
CSC06_RS24475 4328581..4328886 - 306 WP_071527819.1 hypothetical protein -
CSC06_RS24480 4328911..4329150 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CSC06_RS24485 4329150..4329437 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CSC06_RS24490 4329509..4329664 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
CSC06_RS24495 4329881..4330132 + 252 WP_000980994.1 hypothetical protein -
CSC06_RS24500 4330199..4330477 + 279 WP_012304870.1 hypothetical protein -
CSC06_RS24505 4330479..4331528 + 1050 WP_001265198.1 DUF968 domain-containing protein -
CSC06_RS24510 4331542..4332294 + 753 WP_001047135.1 antitermination protein -
CSC06_RS26290 4332572..4332661 - 90 WP_120795389.1 hypothetical protein -
CSC06_RS24515 4332716..4332928 - 213 WP_000087756.1 cold shock-like protein CspF -
CSC06_RS24520 4333229..4333444 + 216 WP_105394433.1 cold shock-like protein CspB -
CSC06_RS26730 4333808..4333978 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
CSC06_RS24525 4334198..4334413 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4317620..4358652 41032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T97463 WP_000323025.1 NZ_CP027140:4329150-4329437 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T97463 NZ_CP027140:4329150-4329437 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT97463 WP_000534858.1 NZ_CP027140:4328911-4329150 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT97463 NZ_CP027140:4328911-4329150 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References