Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 879268..879886 Replicon chromosome
Accession NZ_CP027140
Organism Escherichia coli strain AR_0369

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CSC06_RS06670 Protein ID WP_001291435.1
Coordinates 879668..879886 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CSC06_RS06665 Protein ID WP_000344800.1
Coordinates 879268..879642 (+) Length 125 a.a.

Genomic Context

CSC06_RS06655CSC06_RS06660CSC06_RS06665CSC06_RS06670CSC06_RS06675CSC06_RS06680CSC06_RS06685CSC06_RS06700CSC06_RS06690CSC06_RS06705
Location: 874357..875550 (1194 bp)
Type: Others
Protein ID: WP_001295324.1
Location: 875573..878722 (3150 bp)
Type: Others
Protein ID: WP_105394169.1
Location: 879268..879642 (375 bp)
Type: Antitoxin
Protein ID: WP_000344800.1
Location: 879668..879886 (219 bp)
Type: Toxin
Protein ID: WP_001291435.1
Location: 880058..880609 (552 bp)
Type: Others
Protein ID: WP_000102564.1
Location: 880725..881195 (471 bp)
Type: Others
Protein ID: WP_000136192.1
Location: 881359..882909 (1551 bp)
Type: Others
Protein ID: WP_105394462.1
Location: 883683..883994 (312 bp)
Type: Others
Protein ID: WP_000409911.1
Location: 882951..883304 (354 bp)
Type: Others
Protein ID: WP_000878140.1
Location: 884025..884597 (573 bp)
Type: Others
Protein ID: WP_105394170.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSC06_RS06655874357..875550+1194WP_001295324.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
CSC06_RS06660875573..878722+3150WP_105394169.1efflux RND transporter permease AcrB-
CSC06_RS06665879268..879642+375WP_000344800.1Hha toxicity modulator TomBAntitoxin
CSC06_RS06670879668..879886+219WP_001291435.1hemolysin expression modulator HhaToxin
CSC06_RS06675880058..880609+552WP_000102564.1maltose O-acetyltransferase-
CSC06_RS06680880725..881195+471WP_000136192.1YlaC family protein-
CSC06_RS06685881359..882909+1551WP_105394462.1cyclic-guanylate-specific phosphodiesterase PdeB-
CSC06_RS06690882951..883304-354WP_000878140.1DUF1428 domain-containing protein-
CSC06_RS06700883683..883994+312WP_000409911.1MGMT family protein-
CSC06_RS06705884025..884597-573WP_105394170.1YbaY family lipoprotein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T97443 WP_001291435.1 NZ_CP027140:879668-879886 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T97443 NZ_CP027140:879668-879886 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT97443 WP_000344800.1 NZ_CP027140:879268-879642 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT97443 NZ_CP027140:879268-879642 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
PDB2MW2
PDB1JW2

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U9QBQ5

References