Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 484796..485501 Replicon chromosome
Accession NZ_CP027140
Organism Escherichia coli strain AR_0369

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag CSC06_RS04550 Protein ID WP_000539521.1
Coordinates 484796..485182 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CSC06_RS04555 Protein ID WP_001280945.1
Coordinates 485172..485501 (+) Length 110 a.a.

Genomic Context

CSC06_RS04530CSC06_RS04545CSC06_RS04550CSC06_RS04555CSC06_RS04535CSC06_RS04540CSC06_RS04560CSC06_RS04565CSC06_RS04570
Location: 480800..481426 (627 bp)
Type: Others
Protein ID: WP_001295292.1
Location: 483245..484570 (1326 bp)
Type: Others
Protein ID: WP_000049367.1
Location: 484796..485182 (387 bp)
Type: Toxin
Protein ID: WP_000539521.1
Location: 485172..485501 (330 bp)
Type: Antitoxin
Protein ID: WP_001280945.1
Location: 481423..482538 (1116 bp)
Type: Others
Protein ID: WP_000555031.1
Location: 482649..483032 (384 bp)
Type: Others
Protein ID: WP_000497137.1
Location: 485571..486899 (1329 bp)
Type: Others
Protein ID: WP_000086877.1
Location: 486907..489255 (2349 bp)
Type: Others
Protein ID: WP_105394461.1
Location: 489433..490344 (912 bp)
Type: Others
Protein ID: WP_001236042.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSC06_RS04530480800..481426+627WP_001295292.1glutathione S-transferase GstB-
CSC06_RS04535481423..482538-1116WP_000555031.1aldose sugar dehydrogenase YliI-
CSC06_RS04540482649..483032-384WP_000497137.1biofilm formation regulator BssR-
CSC06_RS04545483245..484570+1326WP_000049367.130S ribosomal protein S12 methylthiotransferase RimO-
CSC06_RS04550484796..485182+387WP_000539521.1type II toxin-antitoxin system RelE/ParE family toxinToxin
CSC06_RS04555485172..485501+330WP_001280945.1DNA-binding transcriptional regulatorAntitoxin
CSC06_RS04560485571..486899-1329WP_000086877.1GGDEF domain-containing protein-
CSC06_RS04565486907..489255-2349WP_105394461.1EAL domain-containing protein-
CSC06_RS04570489433..490344-912WP_001236042.1glutathione ABC transporter permease GsiD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T97442 WP_000539521.1 NZ_CP027140:484796-485182 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T97442 NZ_CP027140:484796-485182 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT97442 WP_001280945.1 NZ_CP027140:485172-485501 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT97442 NZ_CP027140:485172-485501 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCATTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A829GCT6

Antitoxin

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Source
ID
Structure
No matching records found

References