Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 86908..87430 Replicon plasmid unnamed2
Accession NZ_CP027138
Organism Escherichia coli strain AR_0369

Toxin (Protein)


Gene name relE Uniprot ID A9LK42
Locus tag CSC06_RS01870 Protein ID WP_000220562.1
Coordinates 87149..87430 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag CSC06_RS01865 Protein ID WP_000121743.1
Coordinates 86908..87159 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC06_RS01840 82261..83325 + 1065 WP_012291478.1 AAA family ATPase -
CSC06_RS01850 83863..84285 - 423 WP_206354214.1 DNA distortion polypeptide 3 -
CSC06_RS01855 84353..84799 - 447 WP_001074382.1 hypothetical protein -
CSC06_RS01860 84839..85675 - 837 WP_001802123.1 replication initiation protein -
CSC06_RS01865 86908..87159 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
CSC06_RS01870 87149..87430 + 282 WP_000220562.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSC06_RS01875 87576..87899 + 324 WP_001181905.1 hypothetical protein -
CSC06_RS01880 87947..88198 + 252 WP_105394089.1 hypothetical protein -
CSC06_RS01885 88188..88403 + 216 WP_001180117.1 hypothetical protein -
CSC06_RS01890 88496..88825 + 330 WP_000866654.1 hypothetical protein -
CSC06_RS01895 88868..89047 + 180 WP_000439079.1 hypothetical protein -
CSC06_RS26365 89117..89266 + 150 WP_000003879.1 hypothetical protein -
CSC06_RS01905 89279..89551 + 273 WP_000160399.1 hypothetical protein -
CSC06_RS26550 89808..89882 + 75 Protein_119 DNA distortion polypeptide 3 -
CSC06_RS01915 89877..90421 + 545 Protein_120 DNA distortion polypeptide 1 -
CSC06_RS01920 90424..90735 + 312 Protein_121 spore coat protein CotH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / dfrA8 / sul3 / ant(3'')-Ia / catA3 - 1..90735 90735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11021.83 Da        Isoelectric Point: 10.5938

>T97441 WP_000220562.1 NZ_CP027138:87149-87430 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVISVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T97441 NZ_CP027138:87149-87430 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTTGTTATTTCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT97441 WP_000121743.1 NZ_CP027138:86908-87159 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT97441 NZ_CP027138:86908-87159 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9LK42

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References