Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 41460..42007 Replicon plasmid unnamed2
Accession NZ_CP027127
Organism Escherichia coli strain AR_0374

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag CSC11_RS25670 Protein ID WP_000970007.1
Coordinates 41460..41741 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CSC11_RS25675 Protein ID WP_000079941.1
Coordinates 41738..42007 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC11_RS25630 36849..37733 - 885 Protein_50 hypothetical protein -
CSC11_RS25640 38087..38689 + 603 WP_000517695.1 hypothetical protein -
CSC11_RS25645 38745..39239 + 495 WP_001459505.1 hypothetical protein -
CSC11_RS26680 39239..39505 + 267 WP_000955263.1 hypothetical protein -
CSC11_RS25660 39982..40455 - 474 WP_001334658.1 hypothetical protein -
CSC11_RS25665 40572..41420 - 849 WP_001057991.1 3'-5' exonuclease -
CSC11_RS25670 41460..41741 - 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSC11_RS25675 41738..42007 - 270 WP_000079941.1 hypothetical protein Antitoxin
CSC11_RS26540 42062..42220 - 159 WP_000841008.1 hypothetical protein -
CSC11_RS25690 42916..43947 - 1032 WP_000907873.1 replication initiation protein -
CSC11_RS25705 44920..45183 + 264 WP_001324596.1 ash family protein -
CSC11_RS25710 45101..45388 + 288 WP_000074849.1 conjugal transfer protein TraA -
CSC11_RS25725 45996..46649 + 654 WP_106087059.1 conjugal transfer protein TraC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCMY-2 - 1..98987 98987


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T97384 WP_000970007.1 NZ_CP027127:c41741-41460 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T97384 NZ_CP027127:c41741-41460 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT97384 WP_000079941.1 NZ_CP027127:c42007-41738 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT97384 NZ_CP027127:c42007-41738 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References