Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2352160..2352995 Replicon chromosome
Accession NZ_CP027126
Organism Escherichia coli strain AR_0374

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag CSC11_RS12415 Protein ID WP_001094443.1
Coordinates 2352160..2352537 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag CSC11_RS12420 Protein ID WP_001285607.1
Coordinates 2352627..2352995 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC11_RS12385 2347420..2347833 + 414 WP_001368082.1 hypothetical protein -
CSC11_RS12390 2347830..2349299 + 1470 WP_001022619.1 serine/threonine protein kinase -
CSC11_RS12395 2349500..2350765 - 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
CSC11_RS26460 2351227..2351373 - 147 WP_001290178.1 hypothetical protein -
CSC11_RS12405 2351458..2351655 - 198 WP_001327226.1 DUF957 domain-containing protein -
CSC11_RS12410 2351675..2352163 - 489 WP_000761685.1 hypothetical protein -
CSC11_RS12415 2352160..2352537 - 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
CSC11_RS12420 2352627..2352995 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CSC11_RS12425 2353075..2353296 - 222 WP_000692350.1 DUF987 domain-containing protein -
CSC11_RS12430 2353383..2353859 - 477 WP_001186165.1 RadC family protein -
CSC11_RS12435 2353874..2354359 - 486 WP_000206664.1 antirestriction protein -
CSC11_RS12440 2354451..2355269 - 819 WP_001175163.1 DUF945 domain-containing protein -
CSC11_RS12445 2355359..2355592 - 234 WP_001278287.1 DUF905 family protein -
CSC11_RS12450 2355598..2356275 - 678 WP_001097301.1 hypothetical protein -
CSC11_RS12455 2356423..2357103 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) fimC / fimI / fimA / fimE / fimB 2320870..2396766 75896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T97373 WP_001094443.1 NZ_CP027126:c2352537-2352160 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T97373 NZ_CP027126:c2352537-2352160 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT97373 WP_001285607.1 NZ_CP027126:c2352995-2352627 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT97373 NZ_CP027126:c2352995-2352627 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References