Detailed information of TA system TA097358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2330297..2330976
• Replicon: chromosome
• Accession: NZ_CP027123
• Organism: Acinetobacter baumannii strain AR_0056

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: C7R87_RS12555
• Protein ID: WP_000838146.1
• Coordinates: 2330794..2330976 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: C7R87_RS12550
• Protein ID: WP_000966688.1
• Coordinates: 2330297..2330701 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7R87_RS12540	2329253..2329516	-	264	WP_001275792.1	hypothetical protein	-
C7R87_RS12545	2329518..2330198	-	681	WP_000721572.1	hypothetical protein	-
C7R87_RS12550	2330297..2330701	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
C7R87_RS12555	2330794..2330976	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
C7R87_RS12565	2331302..2331817	-	516	WP_032014679.1	hypothetical protein	-
C7R87_RS12570	2331887..2332804	-	918	WP_033841385.1	hypothetical protein	-
C7R87_RS12575	2332857..2334005	-	1149	WP_033841386.1	hypothetical protein	-
C7R87_RS12580	2334005..2334358	-	354	WP_031975507.1	hypothetical protein	-
C7R87_RS12585	2334454..2334672	-	219	WP_001277694.1	hypothetical protein	-
C7R87_RS12590	2334674..2335072	-	399	WP_025466443.1	hypothetical protein	-
C7R87_RS12595	2335074..2335442	-	369	WP_025466445.1	hypothetical protein	-
C7R87_RS12600	2335414..2335821	-	408	WP_000255076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2310262..2364541	54279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T97358 WP_000838146.1 NZ_CP027123:c2330976-2330794 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T97358 NZ_CP027123:c2330976-2330794 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT97358 WP_000966688.1 NZ_CP027123:c2330701-2330297 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT97358 NZ_CP027123:c2330701-2330297 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6