Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3383870..3384488 Replicon chromosome
Accession NZ_CP027118
Organism Escherichia coli strain 26561

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CYQ10_RS17415 Protein ID WP_001291435.1
Coordinates 3384270..3384488 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CYQ10_RS17410 Protein ID WP_000344800.1
Coordinates 3383870..3384244 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYQ10_RS17400 3378959..3380152 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CYQ10_RS17405 3380175..3383324 + 3150 WP_061362233.1 efflux RND transporter permease AcrB -
CYQ10_RS17410 3383870..3384244 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CYQ10_RS17415 3384270..3384488 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CYQ10_RS17420 3384660..3385211 + 552 WP_000102564.1 maltose O-acetyltransferase -
CYQ10_RS17425 3385327..3385797 + 471 WP_000136192.1 YlaC family protein -
CYQ10_RS17430 3385961..3387511 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CYQ10_RS17435 3387553..3387906 - 354 WP_000878140.1 DUF1428 domain-containing protein -
CYQ10_RS17445 3388285..3388596 + 312 WP_000409911.1 MGMT family protein -
CYQ10_RS17450 3388627..3389199 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T97350 WP_001291435.1 NZ_CP027118:3384270-3384488 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T97350 NZ_CP027118:3384270-3384488 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT97350 WP_000344800.1 NZ_CP027118:3383870-3384244 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT97350 NZ_CP027118:3383870-3384244 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References